Gallium(III)-Catalyzed Three-Component (4+3) Cycloaddition Reactions

被引：109
作者：
Han, Xinping [1 ]
Li, Hui [1 ]
Hughes, Russell P. [1 ]
Wu, Jimmy [1 ]
机构：
[1] Dartmouth Coll, Dept Chem, Hanover, NH 03755 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 41期
基金：
美国国家科学基金会;
关键词：
annulation; cycloaddition; heterocycles; gallium; multicomponent reactions; MOLECULAR-ORBITAL METHODS; PHOSPHOROTHIOATE ESTERS; DENSITY FUNCTIONALS; OXYALLYL CATIONS; BASIS-SETS; TRIFLATE; CORE; CONSTRUCTION; DERIVATIVES; ALKYLATION;
D O I：
10.1002/anie.201205238
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Direct approach to indoles: The title reaction generates cyclohepta[b]indole derivatives in a single step at room temperature (see scheme). Exclusion of air or moisture is not required. DFT calculations support a stepwise cyclization event, and the versatility of the method is demonstrated by providing quick access to a library of cyclohepta[b]indole analogues. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：10390 / 10393
页数：4
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