TCTP is induced early in colorectal cancer, it is translationally regulated via the Akt/mTORC1 pathway, and it contributes to the resistance of HCT116 colon cancer cells to 5-FU and oxaliplatin

被引:0
|
作者
Bommer, U. A. [1 ,2 ]
Vine, K. L. [2 ]
Iadevaia, V. [3 ,4 ]
Belfiore, L. [2 ]
Engel, M. [2 ]
Puri, P. [1 ,5 ]
Lochhead, A. [2 ,6 ]
Chen, J. [2 ,7 ]
Fildes, K. [1 ,2 ]
Proud, C. G. [3 ,8 ]
机构
[1] Univ Wollongong, Sch Med, Wollongong, NSW, Australia
[2] Univ Wollongong, Illawarra Hlth & Med Res Inst, Wollongong, NSW, Australia
[3] Univ Southampton, Ctr Biol Sci, Southampton, Hants, England
[4] Univ Surrey, Biologial Sci, Guildford GU2 5XH, Surrey, England
[5] Blacktown Hosp, Western Sydney Local Hlth Dist, Blacktown, NSW, Australia
[6] Southern IML Pathol, Wollongong, NSW, Australia
[7] Univ Queensland, Sch Biomed Sci, St Lucia, Qld, Australia
[8] South Australian Hlth & Med Res Inst, Adelaide, SA, Australia
关键词
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
P04-024
引用
收藏
页码:95 / 95
页数:1
相关论文
共 43 条
  • [31] CRISPR/Cas9-mediated inactivation of miR-34a and miR-34b/c in HCT116 colorectal cancer cells: comprehensive characterization after exposure to 5-FU reveals EMT and autophagy as key processes regulated by miR-34
    Huang, Zekai
    Kaller, Markus
    Hermeking, Heiko
    CELL DEATH AND DIFFERENTIATION, 2023, 30 (08): : 2017 - 2034
  • [32] CRISPR/Cas9-mediated inactivation of miR-34a and miR-34b/c in HCT116 colorectal cancer cells: comprehensive characterization after exposure to 5-FU reveals EMT and autophagy as key processes regulated by miR-34
    Zekai Huang
    Markus Kaller
    Heiko Hermeking
    Cell Death & Differentiation, 2023, 30 : 2017 - 2034
  • [33] Blocking lncRNA NOP14-AS1 overcomes 5-Fu resistance of colon cancer cells by modulating miR-30a-5p-LDHA-glucose metabolism pathway
    Lu, Ya-nan
    DISCOVER ONCOLOGY, 2025, 16 (01)
  • [34] Molecular mechanism of MLCK1 inducing 5-Fu resistance in colorectal cancer cells through activation of TNFR2/NF-κB pathway
    Tang, Huifen
    Zhou, Hui
    Zhang, Liang
    Tang, Tingting
    Li, Ning
    DISCOVER ONCOLOGY, 2024, 15 (01)
  • [35] Syndecan-2, negatively regulated by miR-20b-5p, contributes to 5-fluorouracil resistance of colorectal cancer cells via the JNK/ERK signaling pathway
    Hua, Ruheng
    Zhang, Yan
    Yan, Xiyue
    Tang, Dong
    Li, Xiaolong
    Ni, Qingfeng
    Wang, Daorong
    Zhu, Jianwei
    ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2021, 53 (11) : 1547 - 1557
  • [36] Effects of curcumin on 5-fluorouracil resistance of colon cancer cells through the PI3K/AKT/mTOR pathway via MACC1
    Ma, Xuefeng
    Sun, Xu
    Wang, Rongdi
    Guo, Yutong
    Xu, Meng
    EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE, 2022, 56
  • [37] Overexpressing microRNA-34a overcomes ABCG2-mediated drug resistance to 5-FU in side population cells from colon cancer via suppressing DLL1
    Xie, Zheng-Yuan
    Wang, Fen-Fen
    Xiao, Zhi-Hua
    Liu, Si-Fu
    Tang, Sheng-Lan
    Lai, Yue-Liang
    JOURNAL OF BIOCHEMISTRY, 2020, 167 (06): : 557 - 564
  • [38] ZNF70 regulates IL-1β secretion of macrophages to promote the proliferation of HCT116 cells via activation of NLRP3 inflammasome and STAT3 pathway in colitis-associated colorectal cancer
    Zhang, Zhihong
    Li, Mingyue
    Tai, Yi
    Xing, Yue
    Zuo, Hongxiang
    Jin, Xuejun
    Ma, Juan
    CELLULAR SIGNALLING, 2024, 114
  • [39] Andrographolide Antagonizes INF-α-Induced IL-8 via Inhibition of NADPH Oxidase/ROS/NF-κB and Src/MAPKs/AP-1 Axis in Human Colorectal Cancer HCT116 Cells
    Yuan, Miaomiao
    Meng, Wei
    Liao, Wenzhen
    Lian, Sen
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2018, 66 (20) : 5139 - 5148
  • [40] Apoptosis-induced effects of extract from Artemisia annua Linne by modulating PTEN/p53/PDK1/Akt/ signal pathways through PTEN/p53-independent manner in HCT116 colon cancer cells
    Kim, Eun Ji
    Kim, Guen Tae
    Kim, Bo Min
    Lim, Eun Gyeong
    Kim, Sang-Yong
    Kim, Young Min
    BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2017, 17