The A to G polymorphism at-1082 of the interleukin-10 gene is rare in the Han Chinese population

被引：15

作者：

Guo, Jing ^{[5
]}

He, Yong-Hui ^{[6
,7
]}

Chen, Feng ^{[5
]}

Jiang, Min-Hui ^{[1
,2
]}

Gao, Shu-Ping ^{[3
]}

Su, Ya-Ming ^{[1
,2
]}

Shi, Gui-Liang ^{[4
]}

Deng, Xin-Tao

Zhu, Jian-Hua ^{[1
,2
]}

Pan, Min ^{[1
,2
]}

机构：

[1] Nantong Univ, Affiliated Hosp, Dept Cardiol, Nantong 226001, Peoples R China

[2] Nantong Univ, Inst Cardiovasc Res, Nantong 226001, Peoples R China

[3] Ningxia Peoples Hosp, Dept Cardiol, Yinchuan 750021, Peoples R China

[4] Xinghua Peoples Hosp, Dept Cardiol, Xinghua 225700, Peoples R China

[5] Xinghua Peoples Hosp, Dept Intens Care Unit, Xinghua 225700, Peoples R China

[6] Jiangnan Univ, Peoples Hosp Wuxi 4, Dept Cardiol, Wuxi 216042, Peoples R China

[7] Jiangnan Univ, Affiliated Hosp, Wuxi 216042, Peoples R China

来源：

MOLECULAR MEDICINE REPORTS | 2012年 / 6卷 / 04期

关键词：

interleukin-10; genetic polymorphism; Chinese; CORONARY-ARTERY-DISEASE; NECROSIS-FACTOR-ALPHA; PROMOTER POLYMORPHISM; MYOCARDIAL-INFARCTION; HEART-DISEASE; ASSOCIATION; METAANALYSIS; IL-10; RISK; EXPRESSION;

D O I：

10.3892/mmr.2012.995

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Interleukin-10 (IL-10) is a multifunctional anti-inflammatory cytokine involved in various physiological and pathophysiological processes including cardiovascular disease. It has been reported that 50-75% of the variation in IL-10 production is genetically controlled. In the present study, the IL-10 -1082A/G (rs1800896) polymorphism was detected in 174 coronary artery disease (CAD) patients confirmed by selective coronary angiography and 176 age and gender-matched controls from the Jiangsu area (East China). The majority of the subjects (93:14%) carried the AA wild-type genotype, whereas only 0.29% carried the GG genotype. Our results suggest that IL-10 -1082A/G is rare and unlikely to be a significant contributory to disease susceptibility in the Han Chinese population.

引用

页码：894 / 896

页数：3

共 35 条

[1]

Anand SP, 2007, INDIAN J MED RES, V126, P135

[2]

[Anonymous], BIOCH GENET

[3]

Arosio B, 2010, INT J ALZHEIMERS DIS, V20

[4] IL-10, IL-6 and CD14 polymorphisms and sepsis outcome in ventilated very low birth weight infants [J].

Baier, R. John ;

Loggins, John ;

Yanamandra, Krishna .

BMC MEDICINE, 2006, 4 (1)

[5] IL-10 expression is regulated by HPV E2 protein in cervical cancer cells [J].

Bermudez-Morales, V. H. ;

Peralta-Zaragoza, O. ;

Alcocer-Gonzalez, J. M. ;

Moreno, J. ;

Madrid-Marina, V. .

MOLECULAR MEDICINE REPORTS, 2011, 4 (02) :369-375

[6] Association Between Interleukin-10 Polymorphisms and Alzheimer's Disease: A Systematic Review and Meta-Analysis [J].

Di Bona, Danilo ;

Rizzo, Claudia ;

Bonaventura, Giuseppe ;

Candore, Giuseppina ;

Caruso, Calogero .

JOURNAL OF ALZHEIMERS DISEASE, 2012, 29 (04) :751-759

[7] New polymorphisms in the interleukin-10 gene - relationships to myocardial infarction [J].

Donger, C ;

Georges, JL ;

Nicaud, V ;

Morrison, C ;

Evans, A ;

Kee, F ;

Arveiler, D ;

Tiret, L ;

Cambien, F .

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2001, 31 (01) :9-14

[8] Genotype and interleukin-10 responses after cardiopulmonary bypass [J].

Galley, HF ;

Lowe, PR ;

Carmichael, RL ;

Webster, NR .

BRITISH JOURNAL OF ANAESTHESIA, 2003, 91 (03) :424-426

[9] Polymorphism in the IL10 promoter region and early markers of atherosclerosis: The Cardiovascular Risk in Young Finns Study [J].

Heiskanen, Miikael ;

Kahonen, Mika ;

Hurme, Mikko ;

Lehtimaki, Terho ;

Mononen, Nina ;

Juonala, Markus ;

Hutri-Kahonen, Nina ;

Viikari, Jorma ;

Raitakari, Olli ;

Hulkkonen, Janne .

ATHEROSCLEROSIS, 2010, 208 (01) :190-196

[10] Polymorphisms of tumor necrosis factor-α and interleukin-10 genes in Japanese patients with idiopathic dilated cardiomyopathy [J].

Ito, M ;

Takahashi, H ;

Fuse, K ;

Hirono, S ;

Washizuka, T ;

Kato, K ;

Yamazaki, F ;

Inano, K ;

Furukawa, T ;

Komada, M ;

Aizawa, Y .

JAPANESE HEART JOURNAL, 2000, 41 (02) :183-191

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