Efficient and Convenient Palladium-Catalyzed Amination of Allylic Alcohols with N-Heterocycles

被引:54
作者
Banerjee, Debasis [1 ]
Jagadeesh, Rajenahally V. [1 ]
Junge, Kathrin [1 ]
Junge, Henrik [1 ]
Beller, Matthias [1 ]
机构
[1] Univ Rostock, Leibniz Inst Katalyse, D-18059 Rostock, Germany
关键词
allylic substitution; amination; nitrogen heterocycles; palladium; sustainable chemistry; DIRECT SUBSTITUTION; BORROWING HYDROGEN; PROPARGYLIC ALCOHOLS; PRIMARY AMINES; ALLYLATION; ACTIVATION; LIGANDS; ANALOGS; SULFONAMIDES; COMPLEXES;
D O I
10.1002/anie.201206319
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Atom economic: A commercially available palladium catalyst system is applied for an environmentally benign allylation of electron-deficient N-heterocycles using allylic alcohols (see scheme). The system is also applied for the N-allylation of biologically important uridine and thymidine derivatives. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码:11556 / 11560
页数:5
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