Expression of the estrogen receptor , progesterone receptor and epidermal growth factor receptor in papillary thyroid carcinoma tissues

被引：29

作者：

Chen, Dan ^{[1
]}

Qi, Wenjing ^{[1
]}

Zhang, Pengxin ^{[1
]}

Guan, Hongwei ^{[1
]}

Wang, Lifen ^{[2
]}

机构：

[1] Dalian Med Univ, Dept Pathol, Affiliated Hosp 1, Dalian 116001, Liaoning, Peoples R China

[2] Dalian Med Univ, Dept Pathol, Affiliated Hosp 2, Dalian 116023, Liaoning, Peoples R China

来源：

ONCOLOGY LETTERS | 2015年 / 10卷 / 01期

关键词：

papillary thyroid carcinoma; estrogen receptor; progesterone receptor; epidermal growth factor receptor; BREAST-CANCER; EGF-RECEPTOR; CELL-GROWTH; ACTIVATION; RET/PTC; GENDER; TARGET; RET;

D O I：

10.3892/ol.2015.3223

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The present study aimed to determine the protein expression, in addition to the clinical value of the expression, of estrogen receptor (ER), progesterone receptor (PR) and epidermal growth factor receptor (EGFR) in papillary thyroid carcinoma (PTC). The expression of ER, PR and EGFR was examined immunohistochemically on paraffin-embedded thyroid tissues obtained from 64 patients with PTC and 14 patients with nodular thyroid goiter (NTG). The expression level of ER, PR and EGFR was found to be significantly elevated in the PTC tissues compared with the NTG tissues. In addition, the expression of ER was found to be correlated with the size of PTC tumors. However, there was no significant difference between the expression levels of ER, PR and EGFR in males and females with PTC. Thus, immunohistochemical evaluation of ER, PR and EGFR expression in patients with PTC may aid in the prediction of the prognosis of patients with PTC.

引用

页码：317 / 320

页数：4

共 31 条

[1] PROGNOSTIC IMPACT OF EGF-RECEPTOR IN PAPILLARY THYROID-CARCINOMA [J].

AKSLEN, LA ;

MYKING, AO ;

SALVESEN, H ;

VARHAUG, JE .

BRITISH JOURNAL OF CANCER, 1993, 68 (04) :808-812

[2]

Allred DC, 1998, MODERN PATHOL, V11, P155

[3] Regulation of cell growth by estrogen signaling and potential targets in thyroid cancer [J].

Chen, George G. ;

Vlantis, Alexander C. ;

Zeng, Qiang ;

van Hasselt, C. Andrew .

CURRENT CANCER DRUG TARGETS, 2008, 8 (05) :367-377

[4] RET/PTC-induced cell growth is mediated in part by epidermal growth factor receptor (EGFR) activation: Evidence for molecular and functional interactions between RET and EGFR [J].

Croyle, Michelle ;

Akeno, Nagako ;

Knauf, Jeffrey A. ;

Fabbro, Doriano ;

Chen, Xu ;

Baumgartner, Jacqueline E. ;

Lane, Heidi A. ;

Fagin, James A. .

CANCER RESEARCH, 2008, 68 (11) :4183-4191

[5] Increasing incidence of thyroid cancer in the United States, 1973-2002 [J].

Davies, L ;

Welch, HG .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 295 (18) :2164-2167

[6]

DeLellis RA, 2004, WHO CLASSIFICATION T, P56

[7] Estrogen Induces Metastatic Potential of Papillary Thyroid Cancer Cells through Estrogen Receptor α and β [J].

Dong, Wenwu ;

Zhang, Hao ;

Li, Jing ;

Guan, Haixia ;

He, Liang ;

Wang, Zhihong ;

Shan, Zhongyan ;

Teng, Weiping .

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, 2013, 2013

[8] EPIDERMAL GROWTH-FACTOR RECEPTORS AND ADENYLATE-CYCLASE ACTIVITY IN HUMAN THYROID TISSUES [J].

DUH, QY ;

SIPERSTEIN, AE ;

MILLER, RA ;

SANCHO, JJ ;

DEMEURE, MJ ;

CLARK, OH .

WORLD JOURNAL OF SURGERY, 1990, 14 (03) :410-418

[9] Survival and death causes in differentiated thyroid carcinoma [J].

Eustatia-Rutten, CFA ;

Corssmit, EPM ;

Biermasz, NR ;

Pereira, AM ;

Romijn, JA ;

Smit, JW .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (01) :313-319

[10] EMBRYONIC ESTROGEN-RECEPTORS - DO THEY HAVE A PHYSIOLOGICAL-FUNCTION [J].

GORSKI, J ;

HOU, QF .

ENVIRONMENTAL HEALTH PERSPECTIVES, 1995, 103 :69-72

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