Mathematical model of the glucose-insulin regulatory system: From the bursting electrical activity in pancreatic β-cells to the glucose dynamics in the whole body

被引：8
|
作者：
Han, Kyungreem [3 ,4 ]
Kang, Hyuk [5 ]
Choi, M. Y. [1 ,2 ]
Kim, Jinwoong [3 ,4 ]
Lee, Myung-Shik [6 ,7 ]
机构：
[1] Seoul Natl Univ, Dept Phys & Astron, Seoul 151747, South Korea
[2] Seoul Natl Univ, Ctr Theoret Phys, Seoul 151747, South Korea
[3] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea
[4] Seoul Natl Univ, Pharmaceut Sci Res Inst, Seoul 151742, South Korea
[5] Natl Inst Math Sci, Taejon 305340, South Korea
[6] Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Seoul 135710, South Korea
[7] Sungkyunkwan Univ, Sch Med, Seoul 135710, South Korea
来源：
PHYSICS LETTERS A | 2012年 / 376卷 / 45期
基金：
新加坡国家研究基金会;
关键词：
Mathematical model; Numerical simulation; Emergent property; Glucose-insulin regulatory system; Pancreatic beta-cell function; Insulin resistance; SECRETION; SENSITIVITY; MECHANISMS; RELEASE; RISK; CA2+;
D O I：
10.1016/j.physleta.2012.08.006
中图分类号：
O4 [物理学];
学科分类号：
0702 ;
摘要：
A theoretical approach to the glucose-insulin regulatory system is presented. By means of integrated mathematical modeling and extensive numerical simulations, we probe the cell-level dynamics of the membrane potential, intracellular Ca2+ concentration, and insulin secretion in pancreatic beta-cells, together with the whole-body level glucose-insulin dynamics in the liver, brain, muscle, and adipose tissues. In particular, the three oscillatory modes of insulin secretion are reproduced successfully. Such comprehensive mathematical modeling may provide a theoretical basis for the simultaneous assessment of the beta-cell function and insulin resistance in clinical examination. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：3150 / 3157
页数：8
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