Mathematical model of the glucose-insulin regulatory system: From the bursting electrical activity in pancreatic β-cells to the glucose dynamics in the whole body

被引：8

作者：

Han, Kyungreem ^{[3
,4
]}

Kang, Hyuk ^{[5
]}

Choi, M. Y. ^{[1
,2
]}

Kim, Jinwoong ^{[3
,4
]}

Lee, Myung-Shik ^{[6
,7
]}

机构：

[1] Seoul Natl Univ, Dept Phys & Astron, Seoul 151747, South Korea

[2] Seoul Natl Univ, Ctr Theoret Phys, Seoul 151747, South Korea

[3] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

[4] Seoul Natl Univ, Pharmaceut Sci Res Inst, Seoul 151742, South Korea

[5] Natl Inst Math Sci, Taejon 305340, South Korea

[6] Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Seoul 135710, South Korea

[7] Sungkyunkwan Univ, Sch Med, Seoul 135710, South Korea

来源：

PHYSICS LETTERS A | 2012年 / 376卷 / 45期

基金：

新加坡国家研究基金会;

关键词：

Mathematical model; Numerical simulation; Emergent property; Glucose-insulin regulatory system; Pancreatic beta-cell function; Insulin resistance; SECRETION; SENSITIVITY; MECHANISMS; RELEASE; RISK; CA2+;

D O I：

10.1016/j.physleta.2012.08.006

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

A theoretical approach to the glucose-insulin regulatory system is presented. By means of integrated mathematical modeling and extensive numerical simulations, we probe the cell-level dynamics of the membrane potential, intracellular Ca2+ concentration, and insulin secretion in pancreatic beta-cells, together with the whole-body level glucose-insulin dynamics in the liver, brain, muscle, and adipose tissues. In particular, the three oscillatory modes of insulin secretion are reproduced successfully. Such comprehensive mathematical modeling may provide a theoretical basis for the simultaneous assessment of the beta-cell function and insulin resistance in clinical examination. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：3150 / 3157

页数：8

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