Deep eutectic solvent promoted one-pot synthesis of nitriles from alcohols

被引：4

作者：

Liu, Luxiao ^{[1
]}

Zhang, Hong-Yu ^{[1
]}

Yin, Guohui ^{[1
]}

Zhang, Yuecheng ^{[1
,2
]}

Zhao, Jiquan ^{[1
]}

机构：

[1] Hebei Univ Technol, Sch Chem Engn & Technol, Hebei Prov Key Lab Green Chem Technol & High Effi, Tianjin 300130, Peoples R China

[2] Hebei Univ Technol, Natl Local Joint Engn Lab Energy Conservat Chem P, Tianjin 300130, Peoples R China

来源：

JOURNAL OF CHEMICAL SCIENCES | 2020年 / 132卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Deep eutectic solvent; benzyl alcohols; aryl nitriles; hydroxylamine hydrochloride; TRANSITION-METAL-FREE; AEROBIC OXIDATIVE CONVERSION; BENZYLIC ALCOHOLS; CATALYZED SYNTHESIS; CARBOXYLIC-ACIDS; ARYL NITRILES; EFFICIENT; TEMPO; ALDEHYDES; AMINES;

D O I：

10.1007/s12039-020-01815-z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Various aryl nitriles were readily synthesized from aerobic oxidation of substituted benzyl alcohols in deep eutectic solvent composed of choline chloride (ChCl) andp-toluenesulfonic acid (p-TsOH) in the presence of 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO), followed by condensation with hydroxylamine hydrochloride. High yields of corresponding nitriles have been obtained under mild reactions conditions. This strategy belongs to a novel and environmentally benign transition-metal-free one-pot cascade process for the synthesis of nitriles.

引用

页数：8

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