A dual-targeting hybrid platinum(IV) prodrug for enhancing efficacy

被引：70
作者：
Xiao, Haihua [2 ,3 ]
Yan, Lesan [2 ,3 ]
Zhang, Yu [1 ]
Qi, Ruogu [2 ,3 ]
Li, Wenliang [2 ,3 ]
Wang, Rui [2 ,3 ]
Liu, Shi [2 ,3 ]
Huang, Yubin [2 ]
Li, Yuxin [1 ]
Jing, Xiabin [2 ]
机构：
[1] NE Normal Univ, Natl Engn Lab Druggable Gene & Prot Screening, Changchun 130024, Peoples R China
[2] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
[3] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 87期
基金：
中国国家自然科学基金;
关键词：
CISPLATIN; CANCER; MITOCHONDRIA; COMPLEXES; DRUG;
D O I：
10.1039/c2cc34297a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A multifunctional hybrid platinum(IV) prodrug, which consists of both the mitochondria-targeting drug DCA and the DNA-crosslinking drug cisplatin, was synthesized and tethered to a carrier polymer to further self-assemble into micelles for intracellular delivery.
引用
收藏
页码：10730 / 10732
页数：3
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