Lassa fever in Benin: description of the 2014 and 2016 epidemics and genetic characterization of a new Lassa virus

被引：26

作者：

Yadouleton, Anges ^{[1
]}

Picard, Caroline ^{[2
]}

Rieger, Toni ^{[3
]}

Loko, Frederic ^{[4
]}

Cadar, Daniel ^{[3
]}

Kouthon, Emile Cossi ^{[5
]}

Job, Emmanuel Obolli ^{[6
]}

Bankole, Honore ^{[4
]}

Oestereich, Lisa ^{[3
]}

Gbaguidi, Fernand ^{[7
]}

Pahlman, Meike ^{[3
]}

Becker-Ziaja, Beate ^{[3
]}

Journeaux, Alexandra ^{[1
]}

Pannetier, Delphine ^{[8
]}

Mely, Stephane ^{[8
]}

Mundweiler, Stephanie ^{[8
]}

Thomas, Damien ^{[8
]}

Kohossi, Leon ^{[9
]}

Saizonou, Raoul ^{[9
]}

Kakai, Clement Glele ^{[9
]}

Da Silva, Magloire ^{[4
]}

Kossoubedie, Sonia ^{[9
]}

Kakonku, Andre Lukusa ^{[9
]}

M'Pele, Pierre ^{[9
]}

Gunther, Stephan ^{[3
]}

Baize, Sylvain ^{[1
]}

Fichet-Calvet, Elisabeth ^{[3
]}

机构：

[1] Lab Fievres Hemorrag Virales, Cotonou, Benin

[2] Inst Pasteur, Virol Dept, CNR Fievres Hemorrag Virales CNR FHV, Lyon, France

[3] Bernhard Nocht Inst Trop Med, Virol Dept, Hamburg, Germany

[4] Minist Hlth, Cotonou, Benin

[5] Hosp St Martin de Papane, Papane, Benin

[6] Sanit Coordinat, Tchaourou, Benin

[7] Univ Abomey Calavi, Cotonou, Benin

[8] CNR FHV, Jean Merieux BSL4Lab, INSERM, Lyon, France

[9] WHO, Cotonou, Benin

来源：

EMERGING MICROBES & INFECTIONS | 2020年 / 9卷 / 01期

基金：

欧盟地平线“2020”;

关键词：

Lassa fever; Lassa virus; genome; Benin; outbreak; phylogeny; new lineage; serology; DISEASE; AFRICA; REGION;

D O I：

10.1080/22221751.2020.1796528

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report two outbreaks of Lassa fever that occurred in Benin in 2014 and 2016 with 20 confirmed cases and 50% (10/20) mortality. Benin was not previously considered to be an endemic country for Lassa fever, resulting in a delay to diagnose the disease and its human transmission. Molecular investigations showed the viral genomes to be similar to that of the Togo strain, which is genetically very different from other known strains and confirms the existence of a new lineage. Endemic circulation of Lassa virus in a new territory and the genetic diversity thus confirm that this virus represents a growing threat for West African people. Given the divergence of the Benin strain from the prototypic Josiah Sierra Leone strain frequently used to generate vaccine candidates, the efficacy of vaccine candidates should also be demonstrated with this strain.

引用

页码：1761 / 1770

页数：10

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