Clinical Pharmacogenetics Implementation Consortium Guideline for HLA Genotype and Use of Carbamazepine and Oxcarbazepine: 2017 Update

被引：192

作者：

Phillips, Elizabeth J. ^{[1
]}

Sukasem, Chonlaphat ^{[2
,3
]}

Whirl-Carrillo, Michelle ^{[4
]}

Mueller, Daniel J. ^{[5
,6
]}

Dunnenberger, Henry M. ^{[7
]}

Chantratita, Wasun ^{[8
,9
]}

Goldspiel, Barry ^{[10
]}

Chen, Yuan-Tsong ^{[11
,12
]}

Carleton, Bruce C. ^{[13
,14
]}

George, Alfred L. ^{[15
]}

Mushiroda, Taisei ^{[16
]}

Klein, Teri ^{[4
]}

Gammal, Roseann S. ^{[17
,18
]}

Pirmohamed, Munir ^{[19
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Nashville, TN USA

[2] Mahidol Univ, Ramathibodi Hosp, Fac Med, Div Pharmacogen & Personalized Med,Dept Pathol, Bangkok, Thailand

[3] Ramathibodi Hosp, Fac Med, Somdech Phra Debaratana Med Ctr, Lab Pharmacogen, Bangkok, Thailand

[4] Stanford Univ, Dept Biomed Data Sci, Stanford, CA 94305 USA

[5] Ctr Addict & Mental Hlth, Campbell Family Mental Hlth Res Inst, Toronto, ON, Canada

[6] Univ Toronto, Dept Psychiat & Pharmacol & Toxicol, Toronto, ON, Canada

[7] NorthShore Univ HealthSyst, Ctr Mol Med, Evanston, IL USA

[8] Mahidol Univ, Ramathibodi Hosp, Fac Med, Virol Lab,Dept Pathol, Bangkok, Thailand

[9] Mahidol Univ, Ramathibodi Hosp, Ctr Med Genom, Bangkok, Thailand

[10] NIH, Pharm Dept, Ctr Clin, Bldg 10, Bethesda, MD 20892 USA

[11] Acad Sinica, Inst Biomed Sci, Taipei, Taiwan

[12] Duke Univ, Med Ctr, Dept Pediat, Durham, NC 27710 USA

[13] Univ British Columbia, Fac Med, Dept Pediat, Div Translat Therapeut, Vancouver, BC, Canada

[14] BC Childrens Hosp, Res Inst, Vancouver, BC, Canada

[15] Northwestern Univ, Dept Pharmacol, Feinberg Sch Med, Chicago, IL 60611 USA

[16] RIKEN, Ctr Integrat Med Sci, Lab Pharmacogen, Yokohama, Kanagawa, Japan

[17] MCPHS Univ, Dept Pharm Practice, Boston, MA USA

[18] St Jude Childrens Res Hosp, Dept Pharmaceut Sci, 332 N Lauderdale St, Memphis, TN 38105 USA

[19] Univ Liverpool, Dept Pharmacol, Liverpool, Merseyside, England

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2018年 / 103卷 / 04期

基金：

英国医学研究理事会; 加拿大健康研究院; 加拿大创新基金会; 美国国家卫生研究院;

关键词：

STEVENS-JOHNSON-SYNDROME; TOXIC EPIDERMAL NECROLYSIS; ADVERSE DRUG-REACTIONS; CYTOTOXIC T-CELLS; HLA-B-ASTERISK-1502; ALLELE; B GENOTYPE; HYPERSENSITIVITY REACTIONS; CUTANEOUS REACTIONS; JAPANESE PATIENTS; THAI POPULATION;

D O I：

10.1002/cpt.1004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The variant allele HLA-B*15:02 is strongly associated with greater risk of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in patients treated with carbamazepine or oxcarbazepine. The variant allele HLA-A*31:01 is associated with greater risk of maculopapular exanthema, drug reaction with eosinophilia and systemic symptoms, and SJS/TEN in patients treated with carbamazepine. We summarize evidence from the published literature supporting these associations and provide recommendations for carbamazepine and oxcarbazepine use based on HLA genotypes.

引用

页码：574 / 581

页数：8

共 10 条

[1] Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Carbamazepine Dosing
Leckband, S. G.
Kelsoe, J. R.
Dunnenberger, H. M.
George, A. L., Jr.
Tran, E.
Berger, R.
Mueller, D. J.
Whirl-Carrillo, M.
Caudle, K. E.
Pirmohamed, M.
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2013, 94 (03) : 324 - 328
[2] Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Abacavir Dosing
Martin, M. A.
Klein, T. E.
Dong, B. J.
Pirmohamed, M.
Haas, D. W.
Kroetz, D. L.
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2012, 91 (04) : 734 - 738
[3] Clinical Pharmacogenetics Implementation Consortium Guidelines for Human Leukocyte Antigen-B Genotype and Allopurinol Dosing
Hershfield, M. S.
Callaghan, J. T.
Tassaneeyakul, W.
Mushiroda, T.
Thorn, C. F.
Klein, T. E.
Lee, M. T. M.
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2013, 93 (02) : 153 - 158
[4] Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline forCYP2C9andHLA-BGenotypes and Phenytoin Dosing: 2020 Update
Karnes, Jason H.
Rettie, Allan E.
Somogyi, Andrew A.
Huddart, Rachel
Fohner, Alison E.
Formea, Christine M.
Ta Michael Lee, Ming
Llerena, Adrian
Whirl-Carrillo, Michelle
Klein, Teri E.
Phillips, Elizabeth J.
Mintzer, Scott
Gaedigk, Andrea
Caudle, Kelly E.
Callaghan, John T.
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2021, 109 (02) : 302 - 309
[5] Comparison of the Guidelines of the Clinical Pharmacogenetics Implementation Consortium and the Dutch Pharmacogenetics Working Group
Bank, P. C. D.
Caudle, K. E.
Swen, J. J.
Gammal, R. S.
Whirl-Carrillo, M.
Klein, T. E.
Relling, M. V.
Guchelaar, H-J
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2018, 103 (04) : 599 - 618
[6] Genotype-phenotype association between HLA and carbamazepine-induced hypersensitivity reactions: Strength and clinical correlations
Hsiao, Yi-Hsin
Hui, Rosaline Chung-Yee
Wu, Tony
Chang, Wan-Chun
Hsih, Mo-Song
Yang, Chih-Hsun
Ho, Hsin-Chun
Chang, Ya-Ging
Chen, Ming-Jing
Lin, Jing-Yi
Chen, Ding-Ping
Chang, Pi-Yueh
Wu, Tsu-Lan
Hung, Shuen-Iu
Chung, Wen-Hung
JOURNAL OF DERMATOLOGICAL SCIENCE, 2014, 73 (02) : 101 - 109
[7] Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and HLA-B Genotypes and Phenytoin Dosing
Caudle, K. E.
Rettie, A. E.
Whirl-Carrillo, M.
Smith, L. H.
Mintzer, S.
Lee, M. T. M.
Klein, T. E.
Callaghan, J. T.
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2014, 96 (05) : 542 - 548
[8] Implementation of HLA-B*15:02 Genotyping as Standard-of-Care for Reducing Carbamazepine/Oxcarbazepine Induced Cutaneous Adverse Drug Reactions in Thailand
Tiwattanon, Kanyawan
John, Shobana
Koomdee, Napatrupron
Jinda, Pimonpan
Rachanakul, Jiratha
Jantararoungtong, Thawinee
Nuntharadthanaphong, Nutthan
Kloypan, Chiraphat
Biswas, Mohitosh
Boongird, Apisit
Sukasem, Chonlaphat
FRONTIERS IN PHARMACOLOGY, 2022, 13
[9] Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Tricyclic Antidepressants
Hicks, J. K.
Swen, J. J.
Thorn, C. F.
Sangkuhl, K.
Kharasch, E. D.
Ellingrod, V. L.
Skaar, T. C.
Mueller, D. J.
Gaedigk, A.
Stingl, J. C.
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2013, 93 (05) : 402 - 408
[10] A Joint Consensus Recommendation of the Association for Molecular Pathology, Clinical Pharmacogenetics Implementation Consortium, College of American Pathologists, Dutch Pharmacogenetics Working Group of the Royal Dutch Pharmacists Association, European Society for Pharmacogenomics and Personalized Therapy, and Pharmacogenomics Knowledgebase
Pratt, Victoria M.
Cavallari, Larisa H.
Fulmer, Makenzie L.
Gaedigk, Andrea
Hachad, Houda
Ji, Yuan
Kalman, Lisa, V
Ly, Reynold C.
Moyer, Ann M.
Scott, Stuart A.
van Schaik, Ron H. N.
Whirl-Carrillo, Michelle
Weck, Karen E.
JOURNAL OF MOLECULAR DIAGNOSTICS, 2023, 25 (09) : 619 - 629

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