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CD5 and CD23 expression on B cells in peripheral blood and synovial fluid of rheumatoid arthritis patients:: relationship with interleukin-4, soluble CD23 and tumour necrosis factor alpha levels
被引:8
作者:
Loza, E
Tinturé, T
Sánchez-Ibarrola, A
机构:
[1] Hosp Navarra, Dept Rheumatol, Pamplona 31008, Spain
[2] Univ Navarra, Fac Med, Clin Univ, Dept Immunol, E-31080 Pamplona, Spain
关键词:
CD5+B cells;
CD23;
IL-4;
TNF-alpha;
synovial fluid;
rheumatoid arthritis;
D O I:
10.1093/rheumatology/38.4.325
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Methods. We have studied in peripheral blood (PB) and synovial fluid (SF) of 31 patients diagnosed with rheumatoid arthritis (RA), the expression of CD5 and CD23 antigens on B cells, and the levels of soluble CD23 (sCD23), interleukin-4 (IL-4) and tumour necrosis factor alpha (TNF-cr). We have also correlated the results with the disease activity index. Results. CD5 + B cells are expanded in SF and, moreover, show higher expression of CD23 than CD5 - B cells. Twelve patients had detectable levels of IL-4 in plasma and 10 in SF (nine patients in both samples); the absence of IL-4 was related to a higher expression of CD23 on CD5 + B cells and with higher levels of sCD23. A negative correlation was found in SF between TNF-alpha and sCD23 levels. Conclusion. There is no correlation between disease activity index and the different parameters studied (expression of CD5 and CD23 on B cells, sCD23, IL-4 acid TNF-a levels) either in plasma/PB or in SF.
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页码:325 / 328
页数:4
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