Depression in Parkinson's disease: diagnosis and treatment

被引：0
作者：
de Rezende Costa, Flavio Henrique [1 ]
Zuma Rosso, Ana Lucia [2 ]
Maultasch, Henryk [2 ]
Nicaretta, Denise Hack [4 ]
Vincent, Maurice Borges [3 ]
机构：
[1] Univ Fed Rio de Janeiro, Med Serv Neurol Hosp Univ Clementino Fraga Filho, Rio de Janeiro, RJ, Brazil
[2] Univ Fed Rio de Janeiro, Med Serv Neurol HUCFF UFRJ, Rio de Janeiro, RJ, Brazil
[3] Univ Fed Rio de Janeiro, Fac Med, Rio de Janeiro, RJ, Brazil
[4] UFF, Rio De Janeiro, RJ, Brazil
来源：
ARQUIVOS DE NEURO-PSIQUIATRIA | 2012年 / 70卷 / 08期
关键词：
depression; Parkinson disease; non-motor symptoms; QUALITY-OF-LIFE; NONMOTOR SYMPTOMS; NEUROPSYCHIATRIC SYMPTOMS; STANDARDS SUBCOMMITTEE; PRACTICE PARAMETER; AMERICAN-ACADEMY; NEUROLOGY; DISORDERS; PSYCHOSIS; DEMENTIA;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The prevalence of non-motor symptoms in Parkinson's disease (PD) is high. Depression varies from 20 to 50% of the PD patients, and is associated with increasing disability. The key characteristics of depression are anhedonia and low mood. The recommended scales for screening purposes are: HAM-D, BDI, HADS, MADRS and GDS. As for measurement of severity: HAM-D, MADRS, BDI and SDS. In cases with mild depression, non-pharmacological intervention is the treatment of choice. In moderate depression, antidepressants are required. The choice of an antidepressant should be based mainly on the comorbidities and unique features of the patient. Evidence for antidepressant effectiveness is seen mostly with amitriptyline and nortriptyline, but one should be cautious in elderly patients. Other antidepressants that can be prescribed are: citalopram, escitalopram, sertraline, bupropion, trazodone, venlafaxine, mirtazapine and duloxetin. The dopaminergic agonist pramipexole is a treatment option.
引用
收藏
页码：617 / 620
页数：4
相关论文
共 36 条
  • [1] Practice Parameter: Evaluation and treatment of depression, psychosis, and dementia in Parkinson disease (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology
    Aarsland, D.
    Emre, M.
    Lees, A.
    Poewe, W.
    Ballard, C.
    [J]. NEUROLOGY, 2007, 68 (01) : 80 - 80
  • [2] Neuropsychiatric Symptoms in Parkinson's Disease
    Aarsland, Dag
    Marsh, Laura
    Schrag, Anette
    [J]. MOVEMENT DISORDERS, 2009, 24 (15) : 2175 - 2186
  • [3] Unraveling depression in Parkinson's disease
    Antonini, A.
    [J]. EUROPEAN JOURNAL OF NEUROLOGY, 2008, 15 (09) : 885 - 886
  • [4] The PRIAMO study: background, methods and recruitment
    Antonini, Angelo
    Colosimo, Carlo
    Marconi, Roberto
    Morgante, Letterio
    Barone, Paolo
    [J]. NEUROLOGICAL SCIENCES, 2008, 29 (02) : 61 - 65
  • [5] The Priamo Study: A Multicenter Assessment of Nonmotor Symptoms and Their Impact on Quality of Life in Parkinson's Disease
    Barone, Paolo
    Antonini, Angelo
    Colosimo, Carlo
    Marconi, Roberto
    Morgante, Letterio
    Avarello, Tania P.
    Bottacchi, Eugenio
    Cannas, Antonino
    Ceravolo, Gabriella
    Ceravolo, Roberto
    Cicarelli, Giulio
    Gaglio, Roberto M.
    Giglia, Rosa M.
    Iemolo, Francesco
    Manfredi, Michela
    Meco, Giuseppe
    Nicoletti, Alessandra
    Pederzoli, Massimo
    Petrone, Alfredo
    Pisani, Antonio
    Ponfieri, Francesco E.
    Quatrale, Rocco
    Ramat, Silvia
    Scala, Rosanna
    Volpe, Giuseppe
    Zappulla, Salvatore
    Bentivoglio, Anna Rita
    Stocchi, Fabrizio
    Trianni, Giorgio
    Del Dotto, Paolo
    [J]. MOVEMENT DISORDERS, 2009, 24 (11) : 1641 - 1649
  • [6] Braak H, 2009, ADV ANAT EMBRYOL CEL, V201, P1
  • [7] BRAAK H, 2002, J NEUROL S3, V249, pS1
  • [8] Early Parkinson's disease and non-motor issues
    Chaudhuri, K. Ray
    Naidu, Yogini
    [J]. JOURNAL OF NEUROLOGY, 2008, 255 (Suppl 5) : 33 - 38
  • [9] Non-motor symptoms of Parkinson's disease: diagnosis and management
    Chaudhuri, KR
    Healy, DG
    Schapira, AHV
    [J]. LANCET NEUROLOGY, 2006, 5 (03) : 235 - 245
  • [10] Dias-Tosta E, 2011, ACAD BRASILEIRA NEUR, V1, P62
1234