共 50 条
Elevated troponin levels are associated with early neurological worsening in ischemic stroke with atrial fibrillation
被引:11
|作者:
Nam, Ki-Woong
[1
]
Kim, Chi Kyung
[2
]
Yu, Sungwook
[3
]
Chung, Jong-Won
[4
]
Bang, Oh Young
[4
]
Kim, Gyeong-Moon
[4
]
Jung, Jin-Man
[5
]
Song, Tae-Jin
[6
]
Kim, Yong-Jae
[7
]
Kim, Bum Joon
[8
]
Heo, Sung Hyuk
[8
]
Park, Kwang-Yeol
[9
]
Kim, Jeong-Min
[9
]
Park, Jong-Ho
[10
]
Choi, Jay Chol
[11
]
Park, Man-Seok
[12
]
Kim, Joon-Tae
[12
]
Choi, Kang-Ho
[13
]
Ha Hwang, Yang
[14
]
Seo, Woo-Keun
[4
]
Oh, Kyungmi
[2
]
机构:
[1] Seoul Natl Univ, Dept Neurol, Coll Med, Seoul, South Korea
[2] Korea Univ, Guro Hosp, Coll Med, Dept Neurol, 148 Gurodong Ro, Seoul 08308, South Korea
[3] Korea Univ, Anam Hosp, Coll Med, Dept Neurol, Seoul, South Korea
[4] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurol, 81 Irwon Ro, Seoul 06351, South Korea
[5] Korea Univ, Ansan Hosp, Coll Med, Dept Neurol, Ansan, South Korea
[6] Ewha Womans Univ, Sch Med, Dept Neurol, Seoul, South Korea
[7] Catholic Univ Korea, Dept Neurol, Seoul, South Korea
[8] Kyung Hee Univ, Dept Neurol, Coll Med, Seoul, South Korea
[9] Chung Ang Univ, Chung Ang Univ Hosp, Dept Neurol, Coll Med, Seoul, South Korea
[10] Hanyang Univ, Myongji Hosp, Dept Neurol, Coll Med, Seoul, South Korea
[11] Jeju Natl Univ, Dept Neurol, Jeju, South Korea
[12] Chonnam Natl Univ Hosp, Dept Neurol, Chungnam, South Korea
[13] Chonnam Natl Univ, Hwasun Hosp, Dept Neurol, Hwasun, South Korea
[14] Kyungpook Natl Univ Hosp, Dept Neurol, Daegu, South Korea
基金:
新加坡国家研究基金会;
关键词:
CARDIAC TROPONIN;
EUROPEAN ASSOCIATION;
AMERICAN SOCIETY;
RISK;
ECHOCARDIOGRAPHY;
DETERIORATION;
OUTCOMES;
RECOMMENDATIONS;
UPDATE;
D O I:
10.1038/s41598-020-69303-5
中图分类号:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
Serum cardiac troponin I (cTnI) is often elevated in patients with ischemic stroke, and is associated with their prognosis. Since cTnI is also closely related to atrial fibrillation (AF), cTnI may be a sensitive prognostic indicator in patients with AF-related stroke. This study aimed to evaluate the association between serum cTnI and early neurological deterioration (END) in patients with AF-related stroke. We included consecutive AF-related stroke patients between 2013 and 2015. END was defined as an increase >= 2 in the total NIHSS score or >= 1 in the motor NIHSS score within the first 72 h of admission. A total of 1,133 patients with AF-related stroke were evaluated. In multivariable analysis, cTnI [adjusted odds ratio (aOR)=1.16, 95% confidence interval (CI) 1.00-1.34; P=0.047] remained significant after adjusting for confounders. Initial NIHSS score (aOR=1.03, 95% CI 1.00-1.06; P=0.043) was also positively associated with END; meanwhile, the use of anticoagulants was negatively associated in both vitamin K antagonists (aOR=0.35, 95% CI 0.23-0.54; P<0.001) and new oral anticoagulants (aOR=0.41, 95% CI 0.19-0.89; P=0.024). In conclusion, higher serum cTnI was associated with END in patients with AF-related stroke.
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页数:7
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