Elevated troponin levels are associated with early neurological worsening in ischemic stroke with atrial fibrillation

被引:11
|
作者
Nam, Ki-Woong [1 ]
Kim, Chi Kyung [2 ]
Yu, Sungwook [3 ]
Chung, Jong-Won [4 ]
Bang, Oh Young [4 ]
Kim, Gyeong-Moon [4 ]
Jung, Jin-Man [5 ]
Song, Tae-Jin [6 ]
Kim, Yong-Jae [7 ]
Kim, Bum Joon [8 ]
Heo, Sung Hyuk [8 ]
Park, Kwang-Yeol [9 ]
Kim, Jeong-Min [9 ]
Park, Jong-Ho [10 ]
Choi, Jay Chol [11 ]
Park, Man-Seok [12 ]
Kim, Joon-Tae [12 ]
Choi, Kang-Ho [13 ]
Ha Hwang, Yang [14 ]
Seo, Woo-Keun [4 ]
Oh, Kyungmi [2 ]
机构
[1] Seoul Natl Univ, Dept Neurol, Coll Med, Seoul, South Korea
[2] Korea Univ, Guro Hosp, Coll Med, Dept Neurol, 148 Gurodong Ro, Seoul 08308, South Korea
[3] Korea Univ, Anam Hosp, Coll Med, Dept Neurol, Seoul, South Korea
[4] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurol, 81 Irwon Ro, Seoul 06351, South Korea
[5] Korea Univ, Ansan Hosp, Coll Med, Dept Neurol, Ansan, South Korea
[6] Ewha Womans Univ, Sch Med, Dept Neurol, Seoul, South Korea
[7] Catholic Univ Korea, Dept Neurol, Seoul, South Korea
[8] Kyung Hee Univ, Dept Neurol, Coll Med, Seoul, South Korea
[9] Chung Ang Univ, Chung Ang Univ Hosp, Dept Neurol, Coll Med, Seoul, South Korea
[10] Hanyang Univ, Myongji Hosp, Dept Neurol, Coll Med, Seoul, South Korea
[11] Jeju Natl Univ, Dept Neurol, Jeju, South Korea
[12] Chonnam Natl Univ Hosp, Dept Neurol, Chungnam, South Korea
[13] Chonnam Natl Univ, Hwasun Hosp, Dept Neurol, Hwasun, South Korea
[14] Kyungpook Natl Univ Hosp, Dept Neurol, Daegu, South Korea
基金
新加坡国家研究基金会;
关键词
CARDIAC TROPONIN; EUROPEAN ASSOCIATION; AMERICAN SOCIETY; RISK; ECHOCARDIOGRAPHY; DETERIORATION; OUTCOMES; RECOMMENDATIONS; UPDATE;
D O I
10.1038/s41598-020-69303-5
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Serum cardiac troponin I (cTnI) is often elevated in patients with ischemic stroke, and is associated with their prognosis. Since cTnI is also closely related to atrial fibrillation (AF), cTnI may be a sensitive prognostic indicator in patients with AF-related stroke. This study aimed to evaluate the association between serum cTnI and early neurological deterioration (END) in patients with AF-related stroke. We included consecutive AF-related stroke patients between 2013 and 2015. END was defined as an increase >= 2 in the total NIHSS score or >= 1 in the motor NIHSS score within the first 72 h of admission. A total of 1,133 patients with AF-related stroke were evaluated. In multivariable analysis, cTnI [adjusted odds ratio (aOR)=1.16, 95% confidence interval (CI) 1.00-1.34; P=0.047] remained significant after adjusting for confounders. Initial NIHSS score (aOR=1.03, 95% CI 1.00-1.06; P=0.043) was also positively associated with END; meanwhile, the use of anticoagulants was negatively associated in both vitamin K antagonists (aOR=0.35, 95% CI 0.23-0.54; P<0.001) and new oral anticoagulants (aOR=0.41, 95% CI 0.19-0.89; P=0.024). In conclusion, higher serum cTnI was associated with END in patients with AF-related stroke.
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页数:7
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