Plasma long-chain omega-3 fatty acids and atrophy of the medial temporal lobe

被引：78

作者：

Samieri, Cecilia ^{[1
,4
,5
]}

Maillard, Pauline ^{[6
,7
,8
]}

Crivello, Fabrice ^{[9
,10
,11
]}

Proust-Lima, Cecile ^{[2
,4
,5
]}

Peuchant, Evelyne ^{[12
,13
]}

Helmer, Catherine ^{[3
,4
,5
]}

Amieva, Helene ^{[3
,4
,5
]}

Allard, Michele ^{[14
,15
,16
,17
]}

Dartigues, Jean-Francois ^{[3
,4
,5
]}

Cunnane, Stephen C. ^{[18
]}

Mazoyer, Bernard M. ^{[9
,10
,11
]}

Barberger-Gateau, Pascale ^{[1
,4
,5
]}

机构：

[1] Ctr INSERM U897 Epidemiol Biostat, Equipe Epidemiol Nutr & Comportements Alimentaire, Bordeaux, France

[2] Ctr INSERM U897 Epidemiol Biostat, Equipe Biostat, Bordeaux, France

[3] Ctr INSERM U897 Epidemiol Biostat, Equipe Epidemiol & Neuropsychol Vieillissement Ce, Bordeaux, France

[4] Ctr INSERM U897 Epidemiol Biostat, INSERM, ISPED, Bordeaux, France

[5] Univ Bordeaux, ISPED, Ctr INSERM Epidemiol Biostat U897, Bordeaux, France

[6] CI NAPS, CNRS, UMR6232, Caen, France

[7] DSV I2BM CI NAPS, CEA, Caen, France

[8] Univ Caen Basse Normandie, Caen, France

[9] GIN, CNRS, UMR 5296, Bordeaux, France

[10] GIN, CEA, UMR 5296, Bordeaux, France

[11] Univ Bordeaux, GIN, UMR 5296, Bordeaux, France

[12] INSERM, U876, Bordeaux, France

[13] Hop St Andre, CHU Bordeaux, Dept Biochim, INSERM,U876, Bordeaux, France

[14] CNRS UB1 UB2 Unit, Neurofunct & Cognit Imaging Team, Bordeaux, France

[15] CNRS, CNRS Unit UB1 UB2, Bordeaux, France

[16] Univ Bordeaux, CNRS Unit UB1 UB2, Bordeaux, France

[17] CHU Bordeaux, CNRS Unit UB1 UB2, Nucl Med Serv, Bordeaux, France

[18] Univ Sherbrooke, Res Ctr Aging, Sherbrooke, PQ J1K 2R1, Canada

来源：

NEUROLOGY | 2012年 / 79卷 / 07期

关键词：

ALZHEIMER-DISEASE; DEPRESSIVE SYMPTOMATOLOGY; EICOSAPENTAENOIC ACID; COGNITIVE DECLINE; FISH CONSUMPTION; MRI PREDICTORS; RISK; DEMENTIA; VOLUME; SUPPLEMENTATION;

D O I：

10.1212/WNL.0b013e318264e394

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: The long-chain omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are potential candidates for interventions to delay Alzheimer disease (AD), but evidence from clinical studies is mixed. We aimed at determining whether plasma levels of EPA or DHA predict atrophy of medial temporal lobe (MTL) gray matter regions in older subjects. Methods: A total of 281 community dwellers from the Three-City Study, aged 65 years or older, had plasma fatty acid measurements at baseline and underwent MRI examinations at baseline and at 4 years. We studied the association between plasma EPA and DHA and MTL gray matter volume change at 4 years. Results: Higher plasma EPA, but not DHA, was associated with lower gray matter atrophy of the right hippocampal/parahippocampal area and of the right amygdala (p < 0.05, familywise error corrected). Based on a mean right amygdala volume loss of 6.0 mm(3)/y (0.6%), a 1 SD higher SD higher plasma EPA (+0.64% of total plasma fatty acids) at baseline was related to a 1.3 mm(3) smaller gray matter loss per year in the right amygdala. Higher atrophy of the right amygdala was associated with greater 4-year decline in semantic memory performances and more depressive symptoms. Conclusion: The amygdala, which develops neuropathology in the early stage of AD and is involved in the pathogenesis of depression, may be an important brain structure involved in the association between EPA and cognitive decline and depressive symptoms. Neurology (R) 2012;79:642-650

引用

页码：642 / 650

页数：9