Hybrid Isoprenoids from a Reeds Rhizosphere Soil Derived Actinomycete Streptomyces sp CHQ-64

被引：58

作者：

Che, Qian ^{[1
]}

Zhu, Tianjiao ^{[1
]}

Qi, Xin ^{[1
]}

Mandi, Attila ^{[2
]}

Kurtan, Tibor ^{[2
]}

Mo, Xiaomei ^{[1
]}

Li, Jing ^{[3
]}

Gu, Qianqun ^{[1
]}

Li, Dehai ^{[1
]}

机构：

[1] Ocean Univ China, Sch Med & Pharm, Chinese Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China

[2] Univ Debrecen, Dept Organ Chem, H-4010 Debrecen, Hungary

[3] Ocean Univ China, Coll Marine Life Sci, Qingdao 266003, Peoples R China

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 13期

关键词：

CIRCULAR-DICHROISM; INDOLE ALKALOIDS; BIOSYNTHESIS;

D O I：

10.1021/ol301396h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Indotertine A (1), a hybrid isoprenoid with a condensed pentacyclic skeleton, together with two related hybrid isoprenoids, drimentines F (2) and G (3), were isolated from a reeds rhizosphere soil derived actinomycete Streptomyces sp. CHQ-64. Their structures including absolute configurations were elucidated by spectroscopic methods, X-ray single crystal diffraction analysis, and TDDFT ECD calculations. Drimentines G (3) showed strong cytotoxicity against human cancer cells lines with IC50's down to 1.01 mu M, while 1 and 2 showed no significant activity.

引用

页码：3438 / 3441

页数：4

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