Surface Fouling of Ultrananocrystalline Diamond Microelectrodes during Dopamine Detection: Improving Lifetime via Electrochemical Cycling

被引:20
作者
Chang, An-Yi [1 ]
Dutta, Gaurab [1 ]
Siddiqui, Shabnam [1 ]
Arumugam, Prabhu U. [1 ]
机构
[1] Louisiana Tech Univ, Inst Micromfg, 911 Hergot Ave, Ruston, LA 71272 USA
来源
ACS CHEMICAL NEUROSCIENCE | 2019年 / 10卷 / 01期
基金
美国国家科学基金会;
关键词
Ultrananocrystalline diamond; fouling; electrochemical; cleaning; dopamine; sensitivity; DEEP-BRAIN-STIMULATION; ELECTRON-TRANSFER KINETICS; GLASSY-CARBON ELECTRODES; PARKINSONS-DISEASE; IMPEDANCE SPECTROSCOPY; SENSITIVITY; VOLTAMMETRY; ADSORPTION; RELEASE; NEUROCHEMICALS;
D O I
10.1021/acschemneuro.8b00257
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In this work, we report the electrochemical response of a boron-doped ultrananocrystalline diamond (BDUNCD) micro-electrode during long-term dopamine (DA) detection. Specifically, changes to its electrochemical activity and electroactive area due to DA byproducts and surface oxidation are studied via scanning electron microscopy, energy dispersive spectroscopy, electrochemical impedance spectroscopy, and silver deposition imaging (SDI). The fouling studies with amperometry (AM) and fast scan cyclic voltammetry (FSCV) methods suggest that the microelectrodes are heavily fouled due to poor DA-dopamine-o-quinone cyclization rates followed by a combination of polymer formation and major changes in their surface chemistry. SDI data confirms the presence of the insulating polymer with sparsely distributed tiny electroactive regions. This resulted in severely distorted DA signals and a 90% loss in signal starting as early as 3 h for AM and a 56% loss at 6.5 h for FSCV. This underscores the need for cleaning of the fouled microelectrodes if they have to be used long-term. Out of the three in vivo suitable electrochemical cycling cleaning waveforms investigated, the standard waveform (-0.4 V to +1.0 V) provides the best cleaned surface with a fully retained voltammogram shape, no hysteresis, no DA signal loss (a 90 +/- 0.72 nA increase), and the smallest charge transfer resistance value of 0.4 +/- 0.02 M Omega even after 6.5 h of monitoring. Most importantly, this is the same waveform that is widely used for in vivo detection with carbon fiber microelectrodes. Future work to test these microelectrodes for more than 24 h of DA detection is anticipated.
引用
收藏
页码:313 / 322
页数:19
相关论文
共 74 条
[1]   Influence of the surface termination on the electrochemical properties of boron-doped diamond (BDD) interfaces [J].
Actis, Paolo ;
Denoyelle, Alain ;
Boukherroub, Rabah ;
Szunerits, Sabine .
ELECTROCHEMISTRY COMMUNICATIONS, 2008, 10 (03) :402-406
[2]  
ADAMS RE, 1976, ANAL CHEM, V48, P1989, DOI 10.1021/ac50007a045
[3]   STIMULATION OF THE VENTRAL INTERMEDIATE THALAMIC NUCLEUS IN TREMOR DOMINATED PARKINSONS-DISEASE AND ESSENTIAL TREMOR [J].
ALESCH, F ;
PINTER, MM ;
HELSCHER, RJ ;
FERTL, L ;
BENABID, AL ;
KOOS, WT .
ACTA NEUROCHIRURGICA, 1995, 136 (1-2) :75-81
[4]   FAST SWEEP CYCLIC VOLTAMMETRY AT ULTRA-MICROELECTRODES - EVALUATION OF THE METHOD FOR FAST ELECTRON-TRANSFER KINETIC MEASUREMENTS [J].
ANDRIEUX, CP ;
GARREAU, D ;
HAPIOT, P ;
PINSON, J ;
SAVEANT, JM .
JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 1988, 243 (02) :321-335
[5]   Subsecond adsorption and desorption of dopamine at carbon-fiber microelectrodes [J].
Bath, BD ;
Michael, DJ ;
Trafton, BJ ;
Joseph, JD ;
Runnels, PL ;
Wightman, RM .
ANALYTICAL CHEMISTRY, 2000, 72 (24) :5994-6002
[6]   Deep-brain stimulation in Parkinson's disease:: long-term efficacy and safety -: What happened this year? [J].
Benabid, AL ;
Chabardès, S ;
Seigneuret, E .
CURRENT OPINION IN NEUROLOGY, 2005, 18 (06) :623-630
[7]   A Diamond-Based Electrode for Detection of Neurochemicals in the Human Brain [J].
Bennet, Kevin E. ;
Tomshine, Jonathan R. ;
Min, Hoon-Ki ;
Manciu, Felicia S. ;
Marsh, Michael P. ;
Paek, Seungleal B. ;
Settell, Megan L. ;
Nicolai, Evan N. ;
Blaha, Charles D. ;
Kouzani, Abbas Z. ;
Chang, Su-Youne ;
Lee, Kendall H. .
FRONTIERS IN HUMAN NEUROSCIENCE, 2016, 10
[8]   Effect of sp2-bonded nondiamond carbon impurity on the response of boron-doped polycrystalline diamond thin-film electrodes [J].
Bennett, JA ;
Wang, JA ;
Show, Y ;
Swain, GM .
JOURNAL OF THE ELECTROCHEMICAL SOCIETY, 2004, 151 (09) :E306-E313
[9]   Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein [J].
Bernis, Maria E. ;
Babila, Julius T. ;
Breid, Sara ;
Wuesten, Katharina Annick ;
Wuellner, Ullrich ;
Tamgueney, Gueltekin .
ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2015, 3 :75
[10]   Development of the Wireless Instantaneous Neurotransmitter Concentration System for intraoperative neurochemical monitoring using fast-scan cyclic voltammetry Technical note [J].
Bledsoe, Jonathan M. ;
Kimble, Christopher J. ;
Covey, Daniel P. ;
Blaha, Charles D. ;
Agnesi, Filippo ;
Mohseni, Pedram ;
Whitlock, Sidney ;
Johnson, David M. ;
Horne, April ;
Bennet, Kevin E. ;
Lee, Kendall H. ;
Garris, Paul A. .
JOURNAL OF NEUROSURGERY, 2009, 111 (04) :712-723