Promoter polymorphism in the candidate genes, IL-4, IL-9, TGF-β1, for atopy and asthma

被引：41

作者：

Rosenwasser, LJ ^{[1
]}

机构：

[1] Natl Jewish Med & Res Ctr, Div Clin Immunol & Allergy, Denver, CO 80206 USA

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1999年 / 118卷 / 2-4期

关键词：

cytokines; promoter polymorphisms; atopy; asthma;

D O I：

10.1159/000024096

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

This paper will review genetic variations in the structure of three important candidate genes with varying effects in atopy and asthma that may have significant overall susceptibility associations in relation to the development of atopy and asthma. The three cytokine genes involved are interleukin (IL)-4, IL-9 and transforming growth factor beta 1, and the nature of the polymorphisms may be related to significantly higher outputs of these cytokines in atopy and asthma.

引用

页码：268 / 270

页数：3

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