Promoter polymorphism in the candidate genes, IL-4, IL-9, TGF-β1, for atopy and asthma

被引：41
作者：
Rosenwasser, LJ [1 ]
机构：
[1] Natl Jewish Med & Res Ctr, Div Clin Immunol & Allergy, Denver, CO 80206 USA
来源：
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1999年 / 118卷 / 2-4期
关键词：
cytokines; promoter polymorphisms; atopy; asthma;
D O I：
10.1159/000024096
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
This paper will review genetic variations in the structure of three important candidate genes with varying effects in atopy and asthma that may have significant overall susceptibility associations in relation to the development of atopy and asthma. The three cytokine genes involved are interleukin (IL)-4, IL-9 and transforming growth factor beta 1, and the nature of the polymorphisms may be related to significantly higher outputs of these cytokines in atopy and asthma.
引用
收藏
页码：268 / 270
页数：3
相关论文
共 50 条
  • [21] High risk association of IL-4 VNTR polymorphism with asthma in a North Indian population
    Birbian, Niti
    Singh, Jagtar
    Jindal, Surinder Kumar
    Sobti, Ranbir Chander
    CYTOKINE, 2014, 66 (01) : 87 - 94
  • [22] Haplotypes of the 5′ region of the IL-4 gene and SNPs in the intergene sequence between the IL-4 and IL-13 genes are associated with atopic asthma
    Noguchi, E
    Nukaga-Nishio, Y
    Jian, Z
    Yokouchi, Y
    Kamioka, M
    Yamakawa-Kobayashi, K
    Hamaguchi, H
    Matsui, A
    Shibasaki, M
    Arinami, T
    HUMAN IMMUNOLOGY, 2001, 62 (11) : 1251 - 1257
  • [23] Distinct roles for IL-13 and IL-4 via IL-13 receptor α1 and the type II IL-4 receptor in asthma pathogenesis
    Munitz, A.
    Brandt, E. B.
    Mingler, M.
    Finkelmant, F. D.
    Rothenberg, M. E.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (20) : 7240 - 7245
  • [24] Epistatic effect of IL1A and IL4RA genes on the risk of atopy
    Ådjers, K
    Pessi, T
    Karjalainen, J
    Hutala, H
    Hurme, M
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2004, 113 (03) : 445 - 447
  • [25] IL-4, IL-5, TGF-β1 and IFN-γ mRNAs detected by a new in situ amplification system in cicatricial pemphigoid
    Caproni, M
    Calzolari, A
    Giomi, B
    Santucci, M
    Ficarra, G
    Fabbri, P
    EXPERIMENTAL DERMATOLOGY, 2002, 11 (05) : 421 - 427
  • [26] Polymorphism in the promoter and coding region of the IL-4 receptor alpha-chain gene in atopic children
    Danielewicz, Hanna
    Hurkacz, Magdalena
    Boznanski, Andrzej
    Wiela-Hojenska, Anna
    ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, 2007, 16 (06): : 735 - 741
  • [27] Polymorphism of cytokine genes (TGF-β1, IFN-γ, IL-6, IL-10, and TNF-α) in patients with chronic pancreatitis
    Bendicho, MT
    Guedes, JC
    Silva, NN
    Santana, GO
    dos Santos, RR
    Lyra, AC
    Lyra, LG
    Meyer, R
    Lemaire, DC
    PANCREAS, 2005, 30 (04) : 333 - 336
  • [28] Transplant tolerance associated with a Th1 response and not broken by IL-4, IL-5, and TGF-β blockade or Th1 cytokine administration
    Plain, Karren M.
    Boyd, Rochelle
    Verma, Nirupama D.
    Robinson, Catherine M.
    Tran, Giang T.
    Hodgkinson, Suzanne J.
    Hall, Bruce M.
    TRANSPLANTATION, 2007, 83 (06) : 764 - 773
  • [29] Role of IL-15 in the modulation of TGF-β1-mediated inflammation in asthma
    Jonakowski, Mateusz
    Ziolo, Jan
    Kocwin, Marcelina
    Przemecka, Marcelina
    Mokros, Lukasz
    Panek, Michal
    Szemraj, Janusz
    Kuna, Piotr
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2017, 14 (05) : 4533 - 4540
  • [30] The study of the serum level of IL-4, TGF-β, IFN-γ, and IL-6 in overweight patients with and without diabetes mellitus and hypertension
    Asadikaram, Gholamreza
    Ram, Maryam
    Izadi, Alireza
    Fathollahi, Mahmood Sheikh
    Nematollahi, Mohammad Hadi
    Najafipour, Hamid
    Shahoozehi, Bidollah
    Mirhoseini, Mahboobeh
    Masoumi, Mohammad
    Shahrokhi, Nader
    Arababadi, Mohammad Kazemi
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2019, 120 (03) : 4147 - 4157
12345