Promoter polymorphism in the candidate genes, IL-4, IL-9, TGF-β1, for atopy and asthma

被引：41
|
作者：
Rosenwasser, LJ [1 ]
机构：
[1] Natl Jewish Med & Res Ctr, Div Clin Immunol & Allergy, Denver, CO 80206 USA
来源：
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1999年 / 118卷 / 2-4期
关键词：
cytokines; promoter polymorphisms; atopy; asthma;
D O I：
10.1159/000024096
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
This paper will review genetic variations in the structure of three important candidate genes with varying effects in atopy and asthma that may have significant overall susceptibility associations in relation to the development of atopy and asthma. The three cytokine genes involved are interleukin (IL)-4, IL-9 and transforming growth factor beta 1, and the nature of the polymorphisms may be related to significantly higher outputs of these cytokines in atopy and asthma.
引用
收藏
页码：268 / 270
页数：3
相关论文
共 50 条
  • [1] Genetics of atopy and asthma: Promoter-based candidate gene studies for IL-4
    Rosenwasser, LJ
    INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 1997, 113 (1-3) : 61 - 64
  • [2] Association of TGF-β1, IL-4 and IL-13 gene polymerphisms with asthma in a Chinese population
    Yang, Xue-Xi
    Li, Fen-Xia
    Wu, Ying-Shong
    Wu, Dong
    Tan, Jia-Yu
    Li, Ming
    ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY, 2011, 29 (03) : 273 - 277
  • [3] TGF-β1, IL-10 and IL-4 in colostrum of allergic and nonallergic mothers
    Marek, Andrzej
    Zagierski, Maciej
    Liberek, Anna
    Aleksandrowicz, Ewa
    Korzon, Michal
    Krzykowski, Grzegorz
    Kaminska, Barbara
    Szlagatys-Sidorkiewicz, Agnieszka
    ACTA BIOCHIMICA POLONICA, 2009, 56 (03) : 411 - 414
  • [4] Association of STR polymorphisms in CMA1 and IL-4 with asthma and atopy: The SAPALDIA Cohort
    Hersberger, Martin
    Thun, Gian-Andri
    Imboden, Medea
    Brandstaetter, Anita
    Waechter, Vanessa
    Summerer, Monika
    Schmid-Grendelmeier, Peter
    Bircher, Andreas
    Rohrer, Lucia
    Berger, Wolfgang
    Russi, Erich W.
    Rochat, Thierry
    Kronenberg, Florian
    Probst-Hensch, Nicole
    HUMAN IMMUNOLOGY, 2010, 71 (11) : 1154 - 1160
  • [5] Association of IL-4 promoter polymorphisms with asthma: a meta-analysis
    Tang, L.
    Lin, H. G.
    Chen, B. F.
    GENETICS AND MOLECULAR RESEARCH, 2014, 13 (01): : 1383 - 1394
  • [6] Association of the expression of IL-4 and IL-13 genes, IL-4 and IgE serum levels with allergic asthma
    Afshari, Jalil Tavakkol
    Hosseini, Reza Farid
    Farahabadi, Sara Hesseini
    Heydarian, Farhad
    Boskabady, Mohammad Hossein
    Khoshnavaz, Rasoul
    Razavi, Alireza
    Karimiani, Ehsan Ghayoor
    Ghasemi, Gholamreza
    IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY, 2007, 6 (02) : 67 - 72
  • [7] IL-4, IL-7, IL-9, NT, NRP1 May Be Useful Markers in the Diagnosis of Endometrial Cancer
    Kozlowski, Mateusz
    Borzyszkowska, Dominika
    Lerch, Natalia
    Turon-Skrzypinska, Agnieszka
    Tkacz, Marta
    Lubikowski, Jerzy
    Tarnowski, Maciej
    Rotter, Iwona
    Cymbaluk-Ploska, Aneta
    BIOMOLECULES, 2024, 14 (09)
  • [8] Association analysis of polymorphisms in IL-3, IL-4, IL-5, IL-9, and IL-13 with Graves' disease
    Zhu, W.
    Liu, N.
    Zhao, Y.
    Jia, H.
    Cui, B.
    Ning, G.
    JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2010, 33 (10) : 751 - 755
  • [9] Association between the IL-4 promoter polymorphisms and asthma or severity of hyperresponsiveness in Taiwanese
    Chiang, Chi-Huei
    Tang, Ying-Chuan
    Lin, Ming-Wei
    Chung, Ming-Yi
    RESPIROLOGY, 2007, 12 (01) : 42 - 48
  • [10] Neuronal TGF-β1 mediates IL-9/mast cell interaction and exacerbates excitotoxicity in newborn mice
    Mesplés, B
    Fontaine, RH
    Lelièvre, V
    Launay, JM
    Gressens, P
    NEUROBIOLOGY OF DISEASE, 2005, 18 (01) : 193 - 205
12345