A chemoselective microwave-assisted one-pot cross-Stille reaction of benzylic halides with 2(1H)-pyrazinones using simultaneous cooling

被引：24
作者：
Appukkuttan, Prasad
Husain, Mofazzal
Gupta, Rajinder K.
Parmar, Virinder S.
Van der Eycken, Erik
机构：
[1] Univ Louvain, Dept Chem, B-3001 Louvain, Belgium
[2] Univ Delhi, Dept Chem, Bioorgan Lab, Delhi 100007, India
[3] GGSIP Univ, Sch Biotechnol, Delhi 100006, India
来源：
SYNLETT | 2006年 / 10期
关键词：
microwave; 2(1H)-pyrazinone; Stille; cross-coupling; simultaneous cooling;
D O I：
10.1055/s-2006-941607
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
This manuscript reports the chemoselective one-pot cross-Stille coupling of benzylic halides with 3,5-dichloro-2(1H)-pyrazinones, which avoids the purification and handling of toxic stannylated intermediates. Significant improvements in yields were established when microwave irradiation was performed with simultaneous cooling.
引用
收藏
页码：1491 / 1496
页数：6
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