Polystyrene microplastics induced male reproductive toxicity in mice

被引：425

作者：

Jin, Haibo ^{[1
,2
,3
]}

Ma, Tan ^{[1
,2
,3
]}

Sha, Xiaoxuan ^{[1
,2
,3
]}

Liu, Zhenyu ^{[1
,2
,3
]}

Zhou, Yuan ^{[1
,2
,3
]}

Meng, Xiannan ^{[1
,2
,3
]}

Chen, Yabing ^{[1
,2
,3
]}

Han, Xiaodong ^{[1
,2
,3
]}

Ding, Jie ^{[1
,2
,3
]}

机构：

[1] Nanjing Univ, Sch Med, Immunol & Reprod Biol Lab, Hankou Rd 22, Nanjing 210093, Jiangsu, Peoples R China

[2] Nanjing Univ, Sch Med, State Key Lab Analyt Chem Life Sci, Hankou Rd 22, Nanjing 210093, Jiangsu, Peoples R China

[3] Nanjing Univ, Jiangsu Key Lab Mol Med, Nanjing 210093, Peoples R China

来源：

JOURNAL OF HAZARDOUS MATERIALS | 2021年 / 401卷

基金：

中国国家自然科学基金;

关键词：

MPs; Reproduction; Toxicity; Mammals; BLOOD-TESTIS BARRIER; PLASTIC DEBRIS; MICROBIOTA DYSBIOSIS; ACCUMULATION; GUT; METABOLISM; INGESTION; HORMONE; SERTOLI; CELLS;

D O I：

10.1016/j.jhazmat.2020.123430

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Microplastics (MPs) have become hazardous materials, which have aroused widespread concern about their potential toxicity. However, the effects of MPs on reproductive systems in mammals are still ambiguous. In this study, the toxic effects of polystyrene MPs (PS -MPs) in male reproduction of mice were investigated. The results indicated that after exposure for 24 h, 4 mu m and 10 mu m PS-MPs accumulated in the testis of mice. Meanwhile, 0.5 mu m, 4 mu m, and 10 mu m PS-MPs could enter into three kinds of testicular cells in vitro. In addition, sperm quality and testosterone level of mice were declined after exposure to 0.5 mu m, 4 mu m, and 10 mu m PS-MPs for 28 days. H&E staining showed that spermatogenic cells abscissed and arranged disorderly, and multinucleated gonocytes occurred in the seminiferous tubule. Moreover, PS-MPs induced testicular inflammation and the disruption of blood-testis barrier. In summary, this study demonstrated that PS-MPs induced male reproductive dysfunctions in mice, which provided new insights into the toxicity of MPs in mammals.

引用

页数：11

共 43 条

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