Hypoglycaemic effect of the lyophilised aqueous extract of Ajuga iva in normal and streptozotocin diabetic rats

The purpose of this study was to examine the hypoglycaemic effect of the lyophilised aqueous extract of the whole plant of Ajuga iva (L.) Schreber (Labiatae) in normal and streptozotocin-induced diabetic rats. Single and repeated oral administration of the extract of Ajuga iva L (Al) at a dose of 10 mg/kg produced a slight and significant decrease in plasma glucose levels in normal rats 6 h after administration and after 3 weeks of treatment. Al reduced plasma glucose levels of streptozotocin diabetic rats from 337 +/- 9.3 to 102.2 +/- 17.7 mg/dl after 6 h of oral administration (P < 0.001). Repeated oral administration of Al to streptozotocin diabetic rats significantly decreased the plasma glucose levels after I week of treatment (112 +/- 14.4 mg/dl at 1 week vs 337 +/- 9.3 mg/dl at the baseline values, (P < 0.00 1). It continuously decreased thereafter and showed a rapid normalisation after I week of Al treatment. It is concluded that these results demonstrated that the water extract of the whole plant of Al possess a strong hypoglycaemic effect in diabetic rats, and support therefore. its traditional use in diabetes mellitus control. (C) 2002 Published by Elsevier Science Ireland Ltd.