TSC on the peroxisome controls mTORC1

被引：15

作者：

Benjamin, Don ^{[1
]}

Hall, Michael N. ^{[1
]}

机构：

[1] Univ Basel, Biozentrum, CH-4056 Basel, Switzerland

来源：

NATURE CELL BIOLOGY | 2013年 / 15卷 / 10期

关键词：

ACTIVATION; STRESS;

D O I：

10.1038/ncb2849

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

mTOR is a central controller that integrates many inputs to regulate cell growth and ensure cellular homeostasis. The mTORC1 inhibitor TSC (tuberous sclerosis complex) on the peroxisome is found to inhibit mTORC1 in response to endogenous reactive oxygen species. Thus, mTOR may avoid confounding different inputs by sensing them at different cellular locations.

引用

收藏

页码：1135 / 1136

页数：2

相关论文

共 10 条

[1] ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS [J].

Alexander, Angela ;

Cai, Sheng-Li ;

Kim, Jinhee ;

Nanez, Adrian ;

Sahin, Mustafa ;

MacLean, Kirsteen H. ;

Inoki, Ken ;

Guan, Kun-Liang ;

Shen, Jianjun ;

Person, Maria D. ;

Kusewitt, Donna ;

Mills, Gordon B. ;

Kastan, Michael B. ;

Walker, Cheryl Lyn .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (09) :4153-4158

[2] mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology [J].

Betz, Charles ;

Stracka, Daniele ;

Prescianotto-Baschong, Cristina ;

Frieden, Maud ;

Demaurex, Nicolas ;

Hall, Michael N. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (31) :12526-12534

[3] Localization of Rheb to the endomembrane is critical for its signaling function [J].

Buerger, Claudia ;

DeVries, Ben ;

Stambolic, Vuk .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 344 (03) :869-880

[4] ATM Activation by Oxidative Stress [J].

Guo, Zhi ;

Kozlov, Sergei ;

Lavin, Martin F. ;

Person, Maria D. ;

Paull, Tanya T. .

SCIENCE, 2010, 330 (6003) :517-521

[5] Amino acid signalling upstream of mTOR [J].

Jewell, Jenna L. ;

Russell, Ryan C. ;

Guan, Kun-Liang .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2013, 14 (03) :133-139

[6] Peroxisome assembly: matrix and membrane protein biogenesis [J].

Ma, Changle ;

Agrawal, Gaurav ;

Subramani, Suresh .

JOURNAL OF CELL BIOLOGY, 2011, 193 (01) :7-16

[7] The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1 [J].

Sancak, Yasemin ;

Peterson, Timothy R. ;

Shaul, Yoav D. ;

Lindquist, Robert A. ;

Thoreen, Carson C. ;

Bar-Peled, Liron ;

Sabatini, David M. .

SCIENCE, 2008, 320 (5882) :1496-1501

[8] Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids [J].

Sancak, Yasemin ;

Bar-Peled, Liron ;

Zoncu, Roberto ;

Markhard, Andrew L. ;

Nada, Shigeyuki ;

Sabatini, David M. .

CELL, 2010, 141 (02) :290-303

[9] Dual Specificity Kinase DYRK3 Couples Stress Granule Condensation/Dissolution to mTORC1 Signaling [J].

Wippich, Frank ;

Bodenmiller, Bernd ;

Trajkovska, Maria Gustafsson ;

Wanka, Stefanie ;

Aebersold, Ruedi ;

Pelkmans, Lucas .

CELL, 2013, 152 (04) :791-805

[10] A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS [J].

Zhang, Jiangwei ;

Kim, Jinhee ;

Alexander, Angela ;

Cai, Shengli ;

Tripathi, Durga Nand ;

Dere, Ruhee ;

Tee, Andrew R. ;

Tait-Mulder, Jacqueline ;

Di Nardo, Alessia ;

Han, Juliette M. ;

Kwiatkowski, Erica ;

Dunlop, Elaine A. ;

Dodd, Kayleigh M. ;

Folkerth, Rebecca D. ;

Faust, Phyllis L. ;

Kastan, Michael B. ;

Sahin, Mustafa ;

Walker, Cheryl Lyn .

NATURE CELL BIOLOGY, 2013, 15 (10) :1186-U145