Factorial design as tool in chitosan nanoparticles development by ionic gelation technique

被引：110

作者：

de Pinho Neves, Andreia Lange ^{[1
]}

Milioli, Camila Cardoso ^{[1
]}

Mueller, Leidiani ^{[1
]}

Riella, Humberto Gracher ^{[1
]}

Kuhnen, Nivaldo Cabral ^{[1
]}

Stulzer, Hellen Karine ^{[2
]}

机构：

[1] Univ Fed Santa Catarina, Dept Chem Engn, Labmac Lab Mat & Corros, BR-88040970 Florianopolis, SC, Brazil

[2] Univ Fed Santa Catarina, Lab Qual Control, Dept Pharmaceut Sci, BR-88040970 Florianopolis, SC, Brazil

来源：

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | 2014年 / 445卷

关键词：

Chitosan; Nanoparticles; Tripolyphosphate; Ionic gelation; Experimental design; OPTIMIZATION; DELIVERY; TRIPOLYPHOSPHATE; ANTIBACTERIAL; SYSTEM; CHARGE;

D O I：

10.1016/j.colsurfa.2013.12.058

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Since there are different kinds of chitosan, obtained from different sources of chitin and routes, it is very important to study which are the best conditions in order to obtain nanoparticles with desired size and superficial charge. The aim of this paper was to demonstrate to the scientific community how to obtain chitosan nanoparticles (nanoCTS) with these properties. Ionic gelation technique was applied to form nanoparticles through linkages between tripolyphosphate (TPP) and chitosan (CTS). The formulation was optimized using a 2(3) factorial design to analyze the effect of the pH, CTS:TPP ratio and acetic acid concentration in size and charge of the particles. The best formulation was characterized by FTIR, TGA, EDX and TEM analysis. The formation of nanoCTS depended mainly on ratio of CTS:TPP. Nanoparticles were obtained with excellent conditions for the application in pharmaceutical studies: average diameter of 76.2 nm and zeta potential of 32.6 mV. (c) 2014 Elsevier B.V. All rights reserved.

引用

页码：34 / 39

页数：6

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