Electrospun PDLLA/PLGA composite membranes for potential application in guided tissue regeneration

被引：75
作者：
Zhang Ershuai [1 ]
Zhu Chuanshun [1 ]
Yang Jun [2 ]
Sun Hong [3 ]
Zhang Xiaomin [1 ]
Li Suhua [2 ]
Wang Yonglan [4 ]
Sun Lu [4 ]
Yao Fanglian [1 ]
机构：
[1] Tianjin Univ, Minist Educ, Key Lab Syst Bioengn, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China
[2] Nankai Univ, Coll Life Sci, Key Lab Bioact Mat, Minist Educ, Tianjin 300071, Peoples R China
[3] North China Univ Sci & Technol, Dept Basic Med Sci, Tangshan 063000, Peoples R China
[4] Tianjin Med Univ, Stomatol Hosp, Tianjin 300070, Peoples R China
来源：
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2016年 / 58卷
基金：
中国国家自然科学基金;
关键词：
Electrospinning; Microfiber membranes; Poly(DL-lactic acid) (PDLLA); Poly(DL-lactic-co-glycolic acid) (PLGA); Guided tissue regeneration; IN-VITRO; BIODEGRADABLE POLYMERS; BONE REGENERATION; DRUG-RELEASE; BARRIER MEMBRANES; SCAFFOLDS; DEGRADATION; COLLAGEN; MATRIX; POLY(DL-LACTIDE);
D O I：
10.1016/j.msec.2015.08.032
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
With the aim to explore a membrane system with appropriate degradation rate and excellent cell-occlusiveness for guided tissue regeneration (GTR), a series of poly(D, L.-lactic acid) (PDLLA)/poly(D, L-lactic-co-glycolic acid) (PLGA) (100/0, 70/30, 50/50, 30/70, 0/100, w/w) composite membranes were fabricated via electrospinning. The fabricated membranes were evaluated by morphological characterization, water contact angle measurement and tensile test. In vitro degradation was characterized in terms of the weight loss and the morphological change. Moreover, in vitro cytologic research revealed that PDLLA/PLGA composite membranes could efficiently inhibit the infiltration of 293T cells. Finally, subcutaneous implant test on SD rat in vivo showed that PDLLA/PLGA (70/ 30, 50/50) composite membranes could function well as a physical barrier to prevent cellular infiltration within 13 weeks. These results suggested that electrospun PDLIA/PLGA (50/50) composite membranes could serve as a promising barrier membrane for guided tissue regeneration due to suitable biodegradability, preferable mechanical properties.and excellent cellular shielding effects. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：278 / 285
页数：8
相关论文
共 51 条
  • [11] Investigation of drug release and matrix degradation of electrospun poly(DL-lactide) fibers with paracetanol inoculation[J]. Cui, Wenguo;Li, Xiaohong;Zhu, Xinli;Yu, Guo;Zhou, Shaobing;Weng, Jie. BIOMACROMOLECULES, 2006(05)
  • [12] Gradient nanofibrous chitosan/poly ε-caprolactone scaffolds as extracellular microenvironments for vascular tissue engineering[J]. Du, Fengyi;Wang, Hao;Zhao, Wei;Li, Dong;Kong, Deling;Yang, Jun;Zhang, Yuanyuan. BIOMATERIALS, 2012(03)
  • [13] Polymeric membranes for guided bone regeneration[J]. Gentile, Piergiorgio;Chiono, Valeria;Tonda-Turo, Chiara;Ferreira, Ana M.;Ciardelli, Gianluca. BIOTECHNOLOGY JOURNAL, 2011(10)
  • [14] BIODEGRADABLE POLYMERS FOR USE IN SURGERY - POLYGLYCOLIC-POLY(ACTIC ACID) HOMOPOLYMERS AND COPOLYMERS .1.[J]. GILDING, DK;REED, AM. POLYMER, 1979(12)
  • [15] Alterations of human acellular tissue matrix by gamma irradiation:: Histology, biomechanical property, stability, in vitro cell repopulation, and remodeling[J]. Gouk, Sok-Siam;Lim, Tit-Meng;Teoh, Swee-Hin;Sun, Wendell Q. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2008(01)
  • [16] Attachment, proliferation and collagen type I mRNA expression of human gingival fibroblasts on different biodegradable membranes[J]. Hakki, Sema S.;Korkusuz, Petek;Purali, Nuhan;Bozkurt, Buket;Kus, Mahmut;Duran, Ismet. CONNECTIVE TISSUE RESEARCH, 2013(4-5)
  • [17] A review on polymer nanofibers by electrospinning and their applications in nanocomposites[J]. Huang, ZM;Zhang, YZ;Kotaki, M;Ramakrishna, S. COMPOSITES SCIENCE AND TECHNOLOGY, 2003(15)
  • [18] In vitro biocompatibility of degradable biopolymers in cell line cultures from various ocular tissues: extraction studies[J]. Huhtala, Anne;Pohjonen, Timo;Salminen, Lotta;Salminen, Antero;Kaarniranta, Kai;Uusitalo, Hannu. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2008(02)
  • [19] Porosity of 3D biomaterial scaffolds and osteogenesis[J]. Karageorgiou, V;Kaplan, D. BIOMATERIALS, 2005(27)
  • [20] Kasaj A., 2008, HEAD FACE MED, V4, P1
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