Field trial for assessment of avian influenza vaccination effectiveness in Indonesia

被引：26

作者：

Bouma, A. ^{[1
]}

Muljono, A. Teguh ^{[2
]}

Jatikusumah, A. ^{[2
]}

Nell, A. J. ^{[3
]}

Mudjiartiningsih, S. ^{[4
]}

Dharmayanti, I. ^{[5
]}

Siregar, E. Sawitri ^{[6
]}

Claassen, I. ^{[7
]}

Koch, G. ^{[8
]}

Stegeman, J. A. ^{[1
]}

机构：

[1] Dept Farm Anim Hlth, Fac Vet Med, NL-3584 CN Utrecht, Netherlands

[2] Ctr Indonesian Vet Analyt Studies, Bogor 16000, West Java, Indonesia

[3] Wageningen Int Wageningen Univ & Res Ctr, NL-6701 AN Wageningen, Netherlands

[4] Prov Anim Hlth Lab, Lembang Bandung 40391, Indonesia

[5] Bbalitvet, Bogor 16114, West Java, Indonesia

[6] Minist Agr, Directorate Anim Hlth, Campaign Management Unit, Jakarta, Indonesia

[7] CMU, Indonesia Netherlands Partnership HPAI Prevent Co, Partnership Off, Jakarta, Indonesia

[8] Univ Wageningen & Res Ctr, Cent Vet Inst, Lelystad, Netherlands

来源：

REVUE SCIENTIFIQUE ET TECHNIQUE-OFFICE INTERNATIONAL DES EPIZOOTIES | 2008年 / 27卷 / 03期

关键词：

DIVA; Highly pathogenic avian influenza; Indonesia; Non-Al-vaccinated sentinel; Surveillance; Vaccination;

D O I：

10.20506/rst.27.3.1823

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The aim of this field study was to determine the efficacy of vaccination against highly pathogenic avian influenza (HPAI) virus strain H5N1 in Indonesia. A limited, prototype clinical trial was performed using a standardised treatment group, in which poultry flocks were vaccinated at least twice with a selected H5N1 vaccine, and a control group comprising flocks treated with nonstandardised procedures chosen by the farmer. Each group consisted of six flocks comprising either layers or native chickens. Haemagglutination inhibition (HI) antibody levels were determined by regular serum sampling, and outbreak surveillance relied on non-Al-vaccinated sentinel birds. After three vaccinations high antibody titres were produced in the treatment group, and the percentage of layers with an HI titre > 40 was approximately 90%. Although no conclusions can be drawn regarding reduction of virus transmission, this study demonstrated that 11 farms remained free from Al during the observation period, and that a surveillance programme based on differentiating infected from vaccinated animals (DIVA) can be implemented.

引用

页码：633 / 642

页数：10

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