Review on Anticancer Activity of Essential Metal Dithiocarbamate Complexes

被引：3
作者：
Irfandi, Rizal [1 ,2 ]
Raya, Indah [3 ]
Ahmad, Ahyar [3 ]
Fudholi, Ahmad [4 ,5 ]
Natsir, Hasnah [3 ]
Kartina, Desy [3 ]
Karim, Harningsih [6 ]
Santi, Santi [7 ]
Salnus, Subakir [8 ]
机构：
[1] Hasanuddin Univ, Fac Math & Nat Sci, Dept Chem, Doctoral Program, Jl Perintis Kemerdekaan Km 10 Tamalanrea, Makassar 90245, South Sulawesi, Indonesia
[2] Univ Puangrimaggalatung, Fac Teacher Training & Educ, Dept Biol Educ, Sengkang 90915, South Sulawesi, Indonesia
[3] Hasanuddin Univ, Fac Math & Nat Sci, Dept Chem, Jl Perintis Kemerdekaan Km 10 Tamalanrea, Makassar 90245, South Sulawesi, Indonesia
[4] Univ Kebangsaan Malaysia, Solar Energy Res Inst, Ukm Bangi 43600, Selangor, Malaysia
[5] Kawasan PUSPIPTEK, Indonesian Inst Sci LIPI, Res Ctr Elect Power & Mechatron, Tangerang Selatan 15314, Banten, Indonesia
[6] Sch Pharm YAMASI, Dept Pharm, Jl Mapala 2 Blok D5 10, Makassar 90222, Indonesia
[7] Megarezky Univ, Fac Hlth Technol, Med Lab Technol, Makassar 90234, Indonesia
[8] Coll Panrita Husada Hlth Sci, Dept Med Lab Technol, Jl Panggala, Bulukumba 92561, South Sulawesi, Indonesia
来源：
INDONESIAN JOURNAL OF CHEMISTRY | 2022年 / 22卷 / 06期
关键词：
cytotoxic activity; dithiocarbamate; essential metal; therapeutics; cisplatin; IN-VITRO; STRUCTURAL-CHARACTERIZATION; CELL-DEATH; INHIBITORS; CISPLATIN; NI(II); CHEMISTRY; ZINC(II); ADDUCTS; DESIGN;
D O I：
10.22146/ijc.73738
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The importance of essential metal ions and their metal complexes in the creation of prospective medical therapies has long been recognized. In chemistry, molecular biology, and medicinal fields; the interaction of metal complexes with DNA has been a subject of study. The dithiocarbamate essential metal complex is described extensively in the literature for its various benefits and advantages. With proper use of ligands, it is proven to increase the cytotoxic activity of metal complexes against cancer cells. Some researches have shown significant progress regarding the biological activities of the dithiocarbamate essential metal complex as antimicrobial, antioxidant, and anticancer agents. Metal complexes form complexes with dithiocarbamate ligands with unique structural variations. In this study, we presented an overview of the cytotoxic effects of some dithiocarbamate essential metal complexes on cancer cells, as well as fresh approaches to the design of essential metal-based therapeutics containing dithiocarbamate and molecular targets in cancer therapy. This review may provide an update on recent developments in the medicinal use of essential metals with dithiocarbamate ligands, carried out to identify recent relevant literature. Finally, we predict that the essential metal complexed with dithiocarbamate can be a new breakthrough in the future development of cancer drugs.
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收藏
页码：1722 / 1736
页数：15
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共 75 条
  • [1] Synthesis, characterization and anticancer studies of ferrocenyl complexes containing thiazole moiety
    Abd-Elzaher, Mokhles M.
    Moustafa, Samia A.
    Labib, Ammar A.
    Mousa, Hanan A.
    Ali, Mamdouh M.
    Mahmoud, Abeer E.
    [J]. APPLIED ORGANOMETALLIC CHEMISTRY, 2012, 26 (05) : 230 - 236
  • [2] Platinum group antitumor chemistry: Design and development of new anticancer drugs complementary to cisplatin
    Abu-Surrah, AS
    Kettunen, M
    [J]. CURRENT MEDICINAL CHEMISTRY, 2006, 13 (11) : 1337 - 1357
  • [3] Synthesis, computational and biological studies of alkyltin(IV) N-methyl-N-hydroxyethyl dithiocarbamate complexes
    Adeyemi, Jerry O.
    Saibu, Gbemisola M.
    Olasunkanmi, Lukman O.
    Fadaka, Adewale O.
    Meyer, Mervin
    Sibuyi, Nicole R. S.
    Onwudiwe, Damian C.
    Oyedeji, Adebola O.
    [J]. HELIYON, 2021, 7 (08)
  • [4] Organotin(IV) Dithiocarbamate Complexes: Chemistry and Biological Activity
    Adeyemi, Jerry O.
    Onwudiwe, Damian C.
    [J]. MOLECULES, 2018, 23 (10):
  • [5] DNA Mutations May Not Be the Cause of Cancer
    Adouda Adjiri
    [J]. Oncology and Therapy, 2017, 5 (1) : 85 - 101
  • [6] Targeting triple negative breast cancer cells by N3-substituted 9,10-Phenanthrenequinone thiosemicarbazones and their metal complexes
    Afrasiabi, Zahra
    Stovall, Preston
    Finley, Kristen
    Choudhury, Amitava
    Barnes, Charles
    Ahmad, Aamir
    Sarkar, Fazlul
    Vyas, Alok
    Padhye, Subhash
    [J]. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2013, 114 : 114 - 119
  • [7] Anticancer Potential of Dietary Natural Products: A Comprehensive Review
    Ahmad, Rumana
    Khan, Mohsin A.
    Srivastava, A. N.
    Gupta, Anamika
    Srivastava, Aditi
    Jafri, Tanvir R.
    Siddiqui, Zainab
    Chaubey, Sunaina
    Khan, Tahmeena
    Srivastava, Arvind K.
    [J]. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2020, 20 (02) : 122 - 236
  • [8] Synthesis, characterization and in vitro screening for anticancer potential of Mn(II), Co(II), Cu(II), Zn(II), and Pt(II) methoxyphenyl dithiocarbamato complexes
    Ajibade, Peter A.
    Andrew, Fartisincha P.
    Fatokun, Amos A.
    Oluwalana, Abimbola E.
    [J]. JOURNAL OF MOLECULAR STRUCTURE, 2021, 1230
  • [9] Synthesis, Crystal Structures and Anticancer Studies of Morpholinyldithiocarbamato Cu(II) and Zn(II) Complexes
    Ajibade, Peter A.
    Andrew, Fartisincha P.
    Botha, Nandipha L.
    Solomane, Nolwazi
    [J]. MOLECULES, 2020, 25 (16):
  • [10] Synthesis, characterization and anti-cancer studies of Mn(II), Cu(II), Zn(II) and Pt(II) dithiocarbamate complexes - crystal structures of the Cu(II) and Pt (II) complexes
    Ajibade, Peter A.
    Fatokun, Amos A.
    Andrew, Fartisincha P.
    [J]. INORGANICA CHIMICA ACTA, 2020, 504
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