Cloning of murine cysteine sulfinic acid decarboxylase and its mRNA expression in murine tissues

被引：34

作者：

Park, E

Park, SY

Wang, CH

Xu, J

LaFauci, G

Schuller-Levis, G

机构：

[1] New York State Inst Basic Res Dev Disabil, Dept Immunol, Staten Isl, NY 10314 USA

[2] Konkuk Univ, Dept Vet Med, Seoul, South Korea

[3] New York State Inst Basic Res Dev Disabil, Dept Mol Neurobiol, Staten Isl, NY 10314 USA

[4] New York State Inst Basic Res Dev Disabil, Dept Human Genet, Staten Isl, NY 10314 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 2002年 / 1574卷 / 03期

关键词：

murine cysteine sulfinic acid decarboxylase; sequence of cDNA; taurine; leukocytes; lung;

D O I：

10.1016/S0167-4781(01)00364-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cysteine sulfinic acid decarboxylase (CSD) is the rate-limiting enzyme for biosynthesis of taurine which is essential to biological processes such as development of the brain and eye, reproduction, osmoregulation as well as the anti-inflammatory activity of leukocytes. We report the cDNA sequence of murine CSD that predicts a polypeptide of 493 amino acids. This protein shares 98% and 90% of amino acids with rat and human CSD, respectively, indicating that it is a true ortholog of CSD. Northern blot analysis revealed that CSD mRNA is expressed in kidney and liver, and was not detected in lymphoid tissues and lung. The nucleotide sequence of murine CSD should be useful for genetic manipulation of the CSD gene. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：403 / 406

页数：4

共 24 条

[1] IMMUNOCYTOCHEMISTRY OF THE TAURINE BIOSYNTHESIS ENZYME, CYSTEINE SULFINATE DECARBOXYLASE, IN THE CEREBELLUM - EVIDENCE FOR A GLIAL LOCALIZATION [J].

ALMARGHINI, K ;

REMY, A ;

TAPPAZ, M .

NEUROSCIENCE, 1991, 43 (01) :111-119

[2]

CHATAGNER F, 1951, CR HEBD ACAD SCI, V232, P448

[3] EVIDENCE FOR A RATE-LIMITING ROLE OF CYSTEINESULFINATE DECARBOXYLASE ACTIVITY IN TAURINE BIOSYNTHESIS INVIVO [J].

DELAROSA, J ;

STIPANUK, MH .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 1985, 81 (03) :565-571

[4]

FUKUDA K, 1982, CLIN CHEM, V28, P1758

[5]

GORDON RE, 1986, AM J PATHOL, V125, P585

[6] ANTIOXIDANT ROLE AND SUBCELLULAR LOCATION OF HYPOTAURINE AND TAURINE IN HUMAN NEUTROPHILS [J].

GREEN, TR ;

FELLMAN, JH ;

EICHER, AL ;

PRATT, KL .

BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1073 (01) :91-97

[7]

GRISHAM MB, 1984, J BIOL CHEM, V259, P404

[8] RETINAL DEGENERATION ASSOCIATED WITH TAURINE DEFICIENCY IN CAT [J].

HAYES, KC ;

CAREY, RE ;

SCHMIDT, SY .

SCIENCE, 1975, 188 (4191) :949-951

[9] PYRIDOXAL PHOSPHATE AS THE COENZYME OF THE MAMMALIAN DECARBOXYLASE FOR L-CYSTEINE SULPHINIC AND L-CYSTEIC ACIDS [J].

HOPE, DB .

BIOCHEMICAL JOURNAL, 1955, 59 (03) :497-500

[10] CLONING AND CHARACTERIZATION OF RAT CYSTEINE SULFINIC ACID DECARBOXYLASE [J].

KAISAKIA, PJ ;

JERKINS, AA ;

GOODSPEED, DC ;

STEELE, RD .

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1995, 1262 (01) :79-82

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