Adding Pregabalin or Gabapentin for the Management of Community-Treated Patients with Painful Diabetic Peripheral Neuropathy: A Comparative Cost Analysis

Painful diabetic peripheral neuropathy (pDPN) is a highly prevalent complication of diabetes mellitus, which is associated with substantial costs to society and national health systems. This economic impact varies depending on the therapeutic management provided to patients. The objective of this study was to compare healthcare resource utilization and costs among pDPN patients newly treated with pregabalin or gabapentin in routine medical practice. We performed a retrospective medical records study of pDPN patients newly treated with pregabalin or gabapentin as an add-on therapy who are covered by the Badalona Serveis Assistencials (BSA) health plan, a healthcare provider in Spain, from 2006 to 2009. Healthcare resource utilization and days off work were assessed. The societal perspective was used to estimate costs. Three hundred and ninety-five records were eligible for analysis: 227 (57.5 %) included pregabalin and 168 (42.5 %) gabapentin. Mean (standard deviation) concomitant use of analgesics throughout the study was higher in the gabapentin cohort [3.9 (2.2) vs. 3.1 (2.1); p < 0.05], mainly due to greater use of non-narcotics (78.0 vs. 71.8 %; p < 0.05) and opioids (32.7 vs. 28.6 %; p < 0.05). Healthcare costs accounted for 59.2 % of total costs, of which 71.9 % occurred in primary care, with a mean cost per patient of a,not sign2,476 (year 2010 values). Adjusted mean (95 % CI) total costs were significantly lower in pregabalin-treated patients [a,not sign2,003 (1,427-2,579)] than in gabapentin-treated patients [a,not sign3,127 (2,463-3,790)] (p = 0.013), mainly due to lower healthcare costs [a,not sign1,312 (1,192-1,432) vs. a,not sign1,675 (1,537-1,814); p < 0.001]. Adding pregabalin to existing pDPN therapy resulted in lower total healthcare costs and lower resource utilization than resulted from adding gabapentin.