Copper-mediated Chan-Evans-Lam N-arylation of 5-methylene-4-aryl1,5-dihydro-2H-pyrrol-2-one derivatives

被引：6

作者：

Almohaywi, Basmah ^{[1
,2
]}

Iskander, George ^{[1
]}

Yu, Tsz Tin ^{[1
]}

Bhadbhade, Mohan ^{[3
]}

Black, David St C. ^{[1
]}

Kumar, Naresh ^{[1
]}

机构：

[1] Univ New South Wales, Sch Chem, Sydney, NSW 2052, Australia

[2] King Khalid Univ, Sch Pharm, Abha, Saudi Arabia

[3] UNSW Australia, Mark Wainwright Analyt Ctr, Div Res, Solid State & Elemental Anal Unit, Sydney, NSW 2052, Australia

来源：

TETRAHEDRON LETTERS | 2018年 / 59卷 / 09期

关键词：

Chan-Evans-Lam coupling reaction; Pyrrole-2-one; Quorum sensing; DISCOVERY;

D O I：

10.1016/j.tetlet.2018.01.039

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient procedure for the synthesis of N-aryl 5-methylene-4-aryl-1,5-dihydro-2H-pyrrol2-one derivatives has been developed through copper-mediated C-N bond formation. The synthetic protocol allows for versatile and robust C-N arylation with a range of readily available boronic acids under mild conditions. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：811 / 814

页数：4

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