How do psychedelics work?

被引：88

作者：

Carhart-Harris, Robin L. ^{[1
,2
]}

机构：

[1] Univ Oxford, Dept Psychiat, Ctr Psychedel Res, Oxford, England

[2] Imperial Coll London, Dept Psychiat, Psychedel Res Grp, London, England

来源：

CURRENT OPINION IN PSYCHIATRY | 2019年 / 32卷 / 01期

关键词：

5-HT2A; dimethyltryptamine; lysergic acid diethylamide; psilocybin; psychedelic; psychedelics; serotonin; LIFE-THREATENING CANCER; PSILOCYBIN TREATMENT; ALPHA OSCILLATIONS; PREFRONTAL CORTEX; FREE-ENERGY; SEROTONIN; ANXIETY; 5-HT2A; CONNECTIVITY; DEPRESSION;

D O I：

10.1097/YCO.0000000000000467

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Purpose of review Psychedelics are reawakening interest from psychiatry, cognitive neuroscience and the general public with impressive outcomes in small-scale clinical trials, intriguing human brain imaging work and high-impact journalism. Recent findings This brief opinion piece offers a perspective on how psychedelics work in the brain that may help contextualize these developments. It attempts to link various scales of action, from the molecular (serotonin 2A receptor agonism) through to the anatomical and functional (heightened plasticity) and up to the dynamic (increased brain entropy), systems level (network disintegration and desegregation) and experiential. Summary It is proposed that psychedelics initiate a cascade of neurobiological changes that manifest at multiple scales and ultimately culminate in the relaxation of high-level beliefs. The purpose of psychedelic therapy is to harness the opportunity afforded by this belief-relaxation to achieve a healthy revision of pathological beliefs.

引用

页码：16 / 21

页数：6

共 75 条

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[2] Serotonin, via 5-HT2A receptors, increases EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate release [J].