Hexachlorocyclotriphosphazene (HCCP)-Mediated Direct Formation of Thioethers and Ethers from Quinazolin-4(3H)-ones

被引：7

作者：

Hu, Baoxiang ^{[1
]}

Zhang, Xiaochu ^{[1
]}

Sheng, Lili ^{[1
]}

Guo, Ming ^{[2
]}

Shen, Zhenlu ^{[1
]}

Hu, Xinquan ^{[1
]}

Sun, Nan ^{[1
]}

Mo, Weimin ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Chem Engn & Mat Sci, State Key Lab Breeding Base Green Chem Synth Tech, Hangzhou 310014, Zhejiang, Peoples R China

[2] Zhejiang Agr & Forestry Univ, Dept Chem, Linan 311300, Peoples R China

来源：

MOLECULES | 2013年 / 18卷 / 05期

关键词：

quinazolin-4(3H)-ones; hexachlorocyclotriphosphazene; 4-arylthioquinazolines; 4-aryloxyquinazolines; 4-alkoxyquinazolines; PARASITE PLASMODIUM-FALCIPARUM; BIOLOGICAL EVALUATION; POTENT; INHIBITORS; AGENTS; QUINAZOLINES; DERIVATIVES; DISCOVERY; UREAS; IDENTIFICATION;

D O I：

10.3390/molecules18055580

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A hexachlorocyclotriphosphazene (HCCP)-mediated direct formation of quinazoline (thio) ethers from quinazolin-4(3H)-ones has been developed. Treatment of quinazolin-4(3H)-ones with HCCP, diisopropylethylamine (DIPEA), and thiophenols resulted in formation of the corresponding 4-arylthioquinazoline derivatives in moderate to excellent yields. This method has also been utilized to prepare 4-aryloxyquinazoline and 4-alkoxyquinazoline derivatives using phenols and sodium alkoxides as the nucleophiles.

引用

页码：5580 / 5593

页数：14

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