Calcium Regulation and Bone Mineral Metabolism in Elderly Patients with Chronic Kidney Disease

被引：25

作者：

Tejwani, Vickram ^{[1
]}

Qian, Qi ^{[1
]}

机构：

[1] Mayo Clin, Coll Med, Dept Med, Div Nephrol, Rochester, MN 55905 USA

来源：

NUTRIENTS | 2013年 / 5卷 / 06期

关键词：

calcium homeostasis; aging; chronic kidney disease; mineral and bone disorder; vascular calcification; secondary hyperparathyroidism; FIBROBLAST GROWTH FACTOR-23; VITAMIN-D STATUS; 25-HYDROXYVITAMIN D CONCENTRATION; MOUSE KLOTHO GENE; CARDIOVASCULAR-DISEASE; SECONDARY HYPERPARATHYROIDISM; CA2+-SENSING RECEPTOR; PARATHYROID-HORMONE; VASCULAR CALCIFICATION; ADYNAMIC BONE;

D O I：

10.3390/nu5061913

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The elderly chronic kidney disease (CKD) population is growing. Both aging and CKD can disrupt calcium (Ca2+) homeostasis and cause alterations of multiple Ca2+-regulatory mechanisms, including parathyroid hormone, vitamin D, fibroblast growth factor-23/Klotho, calcium-sensing receptor and Ca2+-phosphate product. These alterations can be deleterious to bone mineral metabolism and soft tissue health, leading to metabolic bone disease and vascular calcification and aging, termed CKD-mineral and bone disorder (MBD). CKD-MBD is associated with morbid clinical outcomes, including fracture, cardiovascular events and all-cause mortality. In this paper, we comprehensively review Ca2+ regulation and bone mineral metabolism, with a special emphasis on elderly CKD patients. We also present the current treatment-guidelines and management options for CKD-MBD.

引用

页码：1913 / 1936

页数：24

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