Animal Models of Disc Degeneration and Major Genetic Strategies

被引：0

作者：

Sun, Fu ^{[1
,2
]}

Qu, Ji-Ning ^{[1
]}

Zhang, Yin-Gang ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Dept Orthoped, Affiliated Hosp 1, Coll Med, Xian 710049, Peoples R China

[2] Xian Med Coll, Affiliated Hosp, Xian, Peoples R China

来源：

PAIN PHYSICIAN | 2013年 / 16卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Disc degeneration; animal model; major gene strategy; exome sequencing; AGE-RELATED-CHANGES; VITAMIN-D-RECEPTOR; FAMILIAL PREDISPOSITION; LUMBAR-DISK; RISK-FACTOR; DISEASE; POLYMORPHISM; ASSOCIATION; COL9A2; CELLS;

D O I：

暂无

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

The establishment of a reliable animal model of lumbar disc degeneration (AMDD) is important for studying pathogenesis and evaluating treatment effectiveness. However, an ideal AMDD for use in laboratory studies has not yet been produced. This retrospective study reviews and compares several common AMDD and discusses their strengths and weaknesses. We also suggest a new method for establishing future AMDD. The identified genes associated with disc degeneration are susceptibility genes, which elevate risk but do not necessarily lead to disease occurrence. We propose to identify families with hereditary disc degeneration, find major casual genes with exome sequencing, and establish transgenic animal models. This approach may help us to build an improved AMDD.

引用

页码：E267 / E275

页数：9