Infection with feline immunodeficiency Virus alters intestinal epithelial transport and mucosal immune responses to probiotics

被引：6

作者：

Stoeker, Laura L. ^{[1
]}

Overman, Elizabeth L. ^{[1
]}

Nordone, Shila K. ^{[1
]}

Moeser, Adam J. ^{[1
]}

Simoes, Rita D. ^{[1
]}

Dean, Gregg A. ^{[2
]}

机构：

[1] N Carolina State Univ, Coll Vet Med, Ctr Comparat Med & Translat Res, Raleigh, NC 27607 USA

[2] Colorado State Univ, Coll Vet Med & Biomed Sci, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA

来源：

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 2013年 / 153卷 / 1-2期

关键词：

HIV; FIV; Lactobacillus; Mucosal immune system; LACTIC-ACID BACTERIA; HIV-INFECTION; T-CELLS; BARRIER; CATS; FIV; MODEL; ACTIVATION; EXPRESSION;

D O I：

10.1016/j.vetimm.2013.01.017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HIV infection is associated with intestinal mucosal dysfunction and probiotics offer the therapeutic potential to enhance the mucosal barrier in HIV+ patients. To evaluate the response of immunocompromised hosts to probiotics, we orally administered Lactobacillus acidophilus to cats with chronic feline immunodeficiency virus (FIV) infection. FIV infection significantly affected transcellular, but not paracellular, transport of small molecules across the intestinal epithelium. Additionally, probiotic treatment of FIV+ cats resulted in changes in cytokine release and mucosal leukocyte percentages that were not paralleled in FIV- cats. These results suggest a novel role for FIV in upregulating transcellular transport across the gastrointestinal epithelial barrier and demonstrate the potential therapeutic use of probiotic bacteria to restore intestinal homeostasis. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：146 / 152

页数：7

共 31 条

[11] Construction of vectors for inducible and constitutive gene expression in Lactobacillus [J].

Duong, Tri ;

Miller, Michael J. ;

Barrangou, Rodolphe ;

Azcarate-Peril, M. Andrea ;

Klaenhammer, Todd R. .

MICROBIAL BIOTECHNOLOGY, 2011, 4 (03) :357-367

[12] Feline Immunodeficiency Virus (FIV) as A Model for Study of Lentivirus Infections: Parallels with HIV [J].

Elder, John H. ;

Lin, Ying-Chuan ;

Fink, Elizabeth ;

Grant, Chris K. .

CURRENT HIV RESEARCH, 2010, 8 (01) :73-80

[13] Damaged Intestinal Epithelial Integrity Linked to Microbial Translocation in Pathogenic Simian Immunodeficiency Virus Infections [J].

Estes, Jacob D. ;

Harris, Levelle D. ;

Klatt, Nichole R. ;

Tabb, Brian ;

Pittaluga, Stefania ;

Paiardini, Mirko ;

Barclay, G. Robin ;

Smedley, Jeremy ;

Pung, Rhonda ;

Oliveira, Kenneth M. ;

Hirsch, Vanessa M. ;

Silvestri, Guido ;

Douek, Daniel C. ;

Miller, Christopher J. ;

Haase, Ashley T. ;

Lifson, Jeffrey ;

Brenchley, Jason M. .

PLOS PATHOGENS, 2010, 6 (08) :49-50

[14] Methodology for isolation and phenotypic characterization of feline small intestinal leukocytes [J].

Howard, KE ;

Fisher, IL ;

Dean, GA ;

Burkhard, MJ .

JOURNAL OF IMMUNOLOGICAL METHODS, 2005, 302 (1-2) :36-53

[15] Effect of 25 weeks probiotic supplementation on immune function of HIV patients [J].

Hummelen, Ruben ;

Changalucha, John ;

Butamanya, Nicodemus L. ;

Koyama, Tara E. ;

Cook, Adrian ;

Habbema, J. Dik F. ;

Reid, Gregor .

GUT MICROBES, 2011, 2 (02) :80-85

[16] Altered Host-Microbe Interaction in HIV: A Target for Intervention with Pro- and Prebiotics [J].

Hummelen, Ruben ;

Vos, Arjan P. ;

van't Land, Belinda ;

van Norren, Klaske ;

Reid, Gregor .

INTERNATIONAL REVIEWS OF IMMUNOLOGY, 2010, 29 (05) :485-513

[17] The Molecular Biology of Feline Immunodeficiency Virus (FIV) [J].

Kenyon, Julia C. ;

Lever, Andrew M. L. .

VIRUSES-BASEL, 2011, 3 (11) :2192-2213

[18] Transport of albumin into the intestinal lumen of the rat [J].

Kimm, MH ;

Hardin, JA ;

Gall, DG .

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1997, 75 (03) :193-198

[19] TNF-α-induced increase in intestinal epithelial tight junction permeability requires NF-κB activation [J].

Ma, TY ;

Iwamoto, GK ;

Hoa, NT ;

Akotia, V ;

Pedram, A ;

Boivin, MA ;

Said, HM .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2004, 286 (03) :G367-G376

[20] Primary intestinal epithelial cells selectively transfer R5 HIV-1 to CCR5+ cells [J].

Meng, G ;

Wei, XP ;

Wu, XY ;

Sellers, MT ;

Decker, JM ;

Moldoveanu, Z ;

Orenstein, JM ;

Graham, MF ;

Kappes, JC ;

Mestecky, J ;

Shaw, GM ;

Smith, PD .

NATURE MEDICINE, 2002, 8 (02) :150-156

← 1 2 3 4 →