Infection with feline immunodeficiency Virus alters intestinal epithelial transport and mucosal immune responses to probiotics

被引：6

作者：

Stoeker, Laura L. ^{[1
]}

Overman, Elizabeth L. ^{[1
]}

Nordone, Shila K. ^{[1
]}

Moeser, Adam J. ^{[1
]}

Simoes, Rita D. ^{[1
]}

Dean, Gregg A. ^{[2
]}

机构：

[1] N Carolina State Univ, Coll Vet Med, Ctr Comparat Med & Translat Res, Raleigh, NC 27607 USA

[2] Colorado State Univ, Coll Vet Med & Biomed Sci, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA

来源：

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 2013年 / 153卷 / 1-2期

关键词：

HIV; FIV; Lactobacillus; Mucosal immune system; LACTIC-ACID BACTERIA; HIV-INFECTION; T-CELLS; BARRIER; CATS; FIV; MODEL; ACTIVATION; EXPRESSION;

D O I：

10.1016/j.vetimm.2013.01.017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HIV infection is associated with intestinal mucosal dysfunction and probiotics offer the therapeutic potential to enhance the mucosal barrier in HIV+ patients. To evaluate the response of immunocompromised hosts to probiotics, we orally administered Lactobacillus acidophilus to cats with chronic feline immunodeficiency virus (FIV) infection. FIV infection significantly affected transcellular, but not paracellular, transport of small molecules across the intestinal epithelium. Additionally, probiotic treatment of FIV+ cats resulted in changes in cytokine release and mucosal leukocyte percentages that were not paralleled in FIV- cats. These results suggest a novel role for FIV in upregulating transcellular transport across the gastrointestinal epithelial barrier and demonstrate the potential therapeutic use of probiotic bacteria to restore intestinal homeostasis. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：146 / 152

页数：7

共 31 条

[1] The Humoral Response to HIV-1: New Insights, Renewed Focus [J].

Alter, Galit ;

Moody, M. Anthony .

JOURNAL OF INFECTIOUS DISEASES, 2010, 202 :S315-S322

[2]

Anukam KC, 2008, J CLIN GASTROENTEROL, V42, P239, DOI 10.1097/MCG.0b013e31802c7465

[3]

ARGENZIO RA, 1990, AM J VET RES, V51, P747

[4] Mucosal administration of low-dose cell-associated feline immunodeficiency virus promotes viral latency [J].

Assogba, Barnabe Dossou ;

Leavell, Sarah ;

Porter, Kyle ;

Burkhard, Mary Jo .

JOURNAL OF INFECTIOUS DISEASES, 2007, 195 (08) :1184-1188

[5] Role of humoral immunity in host defense against HIV [J].

Baum L.L. .

Current HIV/AIDS Reports, 2010, 7 (1) :11-18

[6] Transcytosis of infectious human immunodeficiency virus across a tight human epithelial cell line barrier [J].

Bomsel, M .

NATURE MEDICINE, 1997, 3 (01) :42-47

[7] Microbial translocation is a cause of systemic immune activation in chronic HIV infection [J].

Brenchley, Jason M. ;

Price, David A. ;

Schacker, Timothy W. ;

Asher, Tedi E. ;

Silvestri, Guido ;

Rao, Srinivas ;

Kazzaz, Zachary ;

Bornstein, Ethan ;

Lambotte, Olivier ;

Altmann, Daniel ;

Blazar, Bruce R. ;

Rodriguez, Benigno ;

Teixeira-Johnson, Leia ;

Landay, Alan ;

Martin, Jeffrey N. ;

Hecht, Frederick M. ;

Picker, Louis J. ;

Lederman, Michael M. ;

Deeks, Steven G. ;

Douek, Daniel C. .

NATURE MEDICINE, 2006, 12 (12) :1365-1371

[8] Transmission and immunopathogenesis of FIV in cats as a model for HIV [J].

Burkhard, MJ ;

Dean, GA .

CURRENT HIV RESEARCH, 2003, 1 (01) :15-29

[9] A megalin-like receptor is involved in protein endocytosis in the midgut of an insect (Bombyx mori, Lepidoptera) [J].

Casartelli, M. ;

Cermenati, G. ;

Rodighiero, S. ;

Pennacchio, F. ;

Giordana, B. .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2008, 295 (04) :R1290-R1300

[10] Intranasal bacteria induce Th1 but not Treg or Th2 [J].

Costalonga, M. ;

Cleary, P. P. ;

Fischer, L. A. ;

Zhao, Z. .

MUCOSAL IMMUNOLOGY, 2009, 2 (01) :85-95

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