Changes of lysosomes in the earliest stages of the development of atherosclerosis

被引：16

作者：

Bobryshev, Yuri V. ^{[1
,2
,3
]}

Shchelkunova, Tatyana A. ^{[4
]}

Morozov, Ivan A. ^{[5
]}

Rubtsov, Petr M. ^{[5
]}

Sobenin, Igor A. ^{[6
,7
]}

Orekhov, Alexander N. ^{[3
,7
]}

Smirnov, Alexander N. ^{[4
]}

机构：

[1] Univ New S Wales, Sch Med Sci, Fac Med, Kensington, NSW 2033, Australia

[2] Univ Western Sydney, Sch Med, Campbelltown, NSW, Australia

[3] Skolkovo Innovat Ctr, Atherosclerosis Res Inst, Moscow, Russia

[4] Moscow MV Lomonosov State Univ, Fac Biol, Moscow, Russia

[5] Russian Acad Sci, VA Engelhardt Mol Biol Inst, Moscow, Russia

[6] Russian Cardiol Res & Prod Complex, Moscow, Russia

[7] Russian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Moscow, Russia

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2013年 / 17卷 / 05期

基金：

俄罗斯基础研究基金会;

关键词：

atherosclerosis; initial lesion; fatty streak; aorta; intima; lysosomes; CD68; AMERICAN-HEART-ASSOCIATION; FOAM CELL-FORMATION; INTERMEDIATE LESIONS; VASCULAR-LESIONS; MESSENGER-RNAS; FATTY STREAK; HUMAN AORTA; MACROPHAGES; PROTEINS; DISEASE;

D O I：

10.1111/jcmm.12042

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

One of hypotheses of atherosclerosis is based on a presumption that the zones prone to the development of atherosclerosis contain lysosomes which are characterized by enzyme deficiency and thus, are unable to dispose of lipoproteins. The present study was undertaken to investigate the characteristics and changes of lysosomes in the earliest stages of the development of atherosclerosis. Electron microscopic immunocytochemistry revealed that there were certain changes in the distribution of CD68 antigen in lysosomes along the normal intima-initial lesion-fatty streak' sequence. There were no significant changes found in the key mRNAs encoding for the components of endosome/lysosome compartment in initial atherosclerotic lesions, but in fatty streaks, the contents of EEA1 and Rab5a mRNAs were found to be diminished while the contents of CD68 and p62 mRNAs were increased, compared with the intact tissue. The study reinforces a view that changes occurring in lysosomes play a role in atherogenesis from the very earlier stages of the disease.

引用

页码：626 / 635

页数：10

共 51 条

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