Effects of lowering food intake by high phosphorus diet on parathyroid hormone actions and kidney mineral concentration in rats

被引：10
作者：
Katsumata, S
Matsuzaki, H
Uehara, M
Suzuki, K
机构：
[1] Tokyo Univ Agr, Fac Appl Biosci, Dept Nutr Sci, Setagaya Ku, Tokyo 1568502, Japan
[2] Jr Coll Tokyo Univ Agr, Dept Nutr, Setagaya Ku, Tokyo 1568502, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2006年 / 70卷 / 02期
关键词：
high phosphorus diet; food intake; parathyroid hormone action; kidney mineral concentration;
D O I：
10.1271/bbb.70.528
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We investigated whether lowering food intake by high phosphorus (P) diet influenced parathyroid hormone (PTH) actions, bone turnover markers, and kidney mineral concentration in rats. Rats in two of the three groups were respectively given free access to a control diet (C group) and a high P diet (HP group) for 21 days. Rats in another group (PF group) were pair-fed the control diet with the HP group. Compared to the C and PF groups, serum PTH concentration, urinary C-terminal telopeptide of type I collagen excretion, and kidney calcium and P concentrations were significantly higher in the HP group. Urinary excretion of cAMP was significantly lower in the HP group than in the C and PF groups. These results suggested that high P diet decreased PTH action in the kidney and increased bone resorption and kidney mineral concentrations independently of lowering food intake.
引用
收藏
页码：528 / 531
页数：4
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