A New Perspective on Dry Eye Classification: Proposal by the Asia Dry Eye Society

被引：138

作者：

Tsubota, Kazuo ^{[1
]}

Yokoi, Norihiko ^{[2
]}

Watanabe, Hitoshi ^{[3
]}

Dogru, Murat ^{[1
]}

Kojima, Takashi ^{[1
,4
]}

Yamada, Masakazu ^{[5
]}

Kinoshita, Shigeru ^{[2
]}

Kim, Hyo-Myung ^{[6
]}

Tchah, Hung-Won ^{[7
]}

Hyon, Joon Young ^{[8
]}

Yoon, Kyung Chul ^{[9
]}

Seo, Kyoung Yul ^{[10
]}

Sun, Xuguang ^{[11
]}

Chen, Wei ^{[12
]}

Liang, Lingyi ^{[13
]}

Li, Mingwu ^{[14
]}

Tong, Louis ^{[15
]}

Hu, Fung-Rong ^{[16
]}

Puangsricharern, Vilavun ^{[17
,18
]}

Lim-Bon-Siong, Ruben ^{[19
]}

Yong, Then Kong ^{[20
]}

Liu, Zuguo ^{[21
]}

Shimazaki, Jun ^{[22
]}

机构：

[1] Keio Univ, Sch Med, Dept Ophthalmol, Tokyo, Japan

[2] Kyoto Prefectural Univ Med, Dept Ophthalmol, Kyoto, Japan

[3] Kansai Rosai Hosp, Eye Div, Amagasaki, Hyogo, Japan

[4] Japanese Red Cross Gifu Hosp, Gifu, Japan

[5] Kyorin Univ, Sch Med, Ctr Eye, Tokyo, Japan

[6] Korea Univ, Anam Hosp, Dept Ophthalmol, Seoul, South Korea

[7] Ulsan Univ, Asan Med Ctr, Dept Ophthalmol, Seoul, South Korea

[8] Seoul Natl Univ, Bundang Hosp, Dept Ophthalmol, Seoul, South Korea

[9] Chonnam Natl Univ Hosp, Dept Ophthalmol, Gwangju, South Korea

[10] Yonsei Univ, Severance Hosp, Dept Ophthalmol, Seoul, South Korea

[11] Beijing Inst Ophthalmol, Beijing Tongren Eye Ctr, Dept Ophthalmol, Beijing, Peoples R China

[12] Wenzhou Med Univ, Cornea Serv, Affiliated Eye Hosp, Menzhou, Peoples R China

[13] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, Guangzhou, Peoples R China

[14] Peking Univ Int Hosp, Dept Ophthalmol, Beijing, Peoples R China

[15] Singapore Natl Eye Ctr, Singapore, Singapore

[16] Natl Taiwan Univ Hosp, Dept Ophthalmol, Taipei, Taiwan

[17] Chulalongkorn Univ, Dept Ophthalmol, Bangkok, Thailand

[18] Chulalongkorn Univ, Bangkok, Thailand

[19] Univ Philippines, Dept Ophthalmol, Manila, Philippines

[20] Natl Univ Hosp, Int Specialist Eye Ctr, Kuala Lumpur, Malaysia

[21] Xiamen Univ, Inst Eye, Xiamen, Peoples R China

[22] Tokyo Dent Coll, Dept Ophthalmol, Ichikawa, Japan

来源：

EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE | 2020年 / 46卷

关键词：

Asia Dry Eye Society; Classification; Dry eye; Tear film-oriented therapy; Tear film stability; DIQUAFOSOL OPHTHALMIC SOLUTION; MEIBOMIAN GLAND DYSFUNCTION; BREAK-UP TIME; VERSUS-HOST-DISEASE; TEAR FILM; OCULAR SURFACE; RISK-FACTORS; OFFICE WORKERS; REFLECTIVE MENISCOMETRY; REBAMIPIDE INCREASES;

D O I：

10.1097/ICL.0000000000000643

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The 2017 consensus report of the Asia Dry Eye Society (ADES) on the definition and diagnosis of dry eyes described dry eye disease as "Dry eye is a multifactorial disease characterized by unstable tear film causing a variety of symptoms and/or visual impairment, potentially accompanied by ocular surface damage." The report emphasized the instability of tear film and the importance of visual dysfunction in association with dry eyes, highlighting the importance of the evaluation of tear film stability. This report also discussed the concept of tear film-oriented therapy, which stemmed from the definition, and which is centered on provision of insufficient components in each tear film layer and ocular surface epithelium. The current ADES report proposes a simple classification of dry eyes based on the concept of tear film-oriented diagnosis and suggests that there are three types of dry eye: aqueous-deficient, decreased wettability, and increased evaporation. It is suggested that these three types respectively coincide with the problems of each layer: aqueous, membrane-associated mucins, and lipid/secretory mucin. Although each component cannot be quantitatively evaluated with the current technology, a practical diagnosis based on the patterns of fluorescein breakup is recommended. The Asia Dry Eye Society classification report suggests that for a practical use of the definition, diagnostic criteria and classification system should be integrated and be simple to use. The classification system proposed by ADES is a straightforward tool and simple to use, only through use of fluorescein, which is available even to non-dry eye specialists, and which is believed to contribute to an effective diagnosis and treatment of dry eyes.

引用

页码：S2 / S13

页数：12

共 120 条

[1]

ADAMS AD, 1979, ARCH OPHTHALMOL-CHIC, V97, P730

[2] MUC16 mucin is expressed by the human ocular surface epithelia and carries the H185 carbohydrate epitope [J].