NIR-Triggered Anticancer Drug Delivery by Upconverting Nanoparticles with Integrated Azobenzene-Modified Mesoporous Silica

被引：669
作者：
Liu, Jianan [1 ]
Bu, Wenbo [1 ]
Pan, Limin [1 ]
Shi, Jianlin [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 16期
基金：
中国国家自然科学基金;
关键词：
cancer; drug delivery; mesoporous materials; upconverting nanoparticles; NEAR-INFRARED LIGHT; UP-CONVERSION LUMINESCENCE; IN-VITRO; RELEASE; THERAPY;
D O I：
10.1002/anie.201300183
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Photomediated drug release: Silica-coated upconverting nanoparticles with mesopores modified by azobenzene molecules were synthesized. The azobenzene molecules make possible the release of the anticancer drug doxorubicin from the pore network of the mesoporous silica outer layer by irradiation with near-infrared (NIR) laser light. The release is regulated by the trans-cis photoisomerization of the azobenzene molecules (see picture). Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：4375 / 4379
页数：5
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