The antimicrobial properties of some copper(II) and platinum(II) 1,10-phenanthroline complexes

被引:75
|
作者
Ng, Neville S. [1 ]
Leverett, Peter [1 ]
Hibbs, David E. [2 ]
Yang, Qianfan [3 ]
Bulanadi, Jerikho C. [1 ]
Wu, Ming Jie [1 ]
Aldrich-Wright, Janice R. [1 ]
机构
[1] Univ Western Sydney, Sch Sci & Hlth, Penrith, NSW 2751, Australia
[2] Univ Sydney, Fac Pharm, Sydney, NSW 2006, Australia
[3] Chinese Acad Sci ICCAS, State Key Lab Struct Chem Unstable & Stable Speci, Ctr Mol Sci, BNLMS,Inst Chem, Beijing 100190, Peoples R China
关键词
COORDINATION-COMPOUNDS; DIMETHYL-SULFOXIDE; CYTOTOXIC ACTIVITY; DNA CLEAVAGE; ANTIBACTERIAL; METALLOINTERCALATORS; PERMEABILITY; ANTIBIOTICS; ANTIFUNGAL; TRANSITION;
D O I
10.1039/c2dt32392c
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Copper(II) (1(Cu)-21(Cu)) and previously established experimental anticancer platinum(II) metallointercalator complexes (1(Pt)-16(Pt)) have been prepared and investigated for their antimicrobial properties. These complexes are of the general structure [M(I-L)(A(L))](2+) where I-L represents functionalised 1,10-phenanthrolines (1(IL)-10(IL)), and A(L) represents 1,2-diaminoethane, 1S,2S- or 1R,2R-diaminocyclohexane. The structures of synthesised complexes were confirmed using a combination of elemental analysis, UV spectrometry, circular dichroism, H-1 and [H-1-Pt-195]-HMQC NMR, X-ray crystallography, and electrospray ionisation mass spectrometry and where appropriate. Crystallisation attempts yielded single crystals of [Cu(4-methyl-1,10-phenanthroline)(1R,2R-diaminocyclohexane)](ClO4)(2) (4(Cu)), [Cu(5,6- dimethyl-1,10-phenanthroline)(1R,2R-diaminocyclohexane)(H2O)](ClO4)(2)center dot 1.5H(2)O (10(Cu)) and [Cu(5,6-dimethyl-1,10-phenanthroline)(3)]-(ClO4)(2)center dot 5,6-dimethyl-1,10-phenanthroline center dot 2H(2)O (21(Cu)). Growth inhibition of liquid cultures of bacteria (Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa), and yeast (Saccharomyces cerevisiae) discerned the most antimicrobially potent metal complexes <= 20 mu M, as well as that of their intercalating ligands alone. To further investigate their mode of antimicrobial activity, membrane permeabilisation caused by selected complexes was visualised by means of a cell viability kit under fluorescence microscopy.
引用
收藏
页码:3196 / 3209
页数:14
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