Reduced antibody responses against Plasmodium falciparum vaccine candidate antigens in the presence of Trichuris trichiura

被引：42

作者：

Esen, Meral ^{[1
,2
,3
]}

Mordmueller, Benjamin ^{[1
,2
,3
]}

de Salazar, Pablo Martinez ^{[1
,2
,3
]}

Adegnika, Ayola Akim ^{[1
,2
,3
,4
]}

Agnandji, Selidji Todagbe ^{[1
,2
,3
]}

Schaumburg, Frieder ^{[1
,2
,3
]}

Hounkpatin, Aurore Bouyoukou ^{[1
,2
,3
]}

Brueckner, Sina ^{[1
]}

Theisen, Michael ^{[5
,6
]}

Belard, Sabine ^{[1
,2
,3
]}

Ngoa, Ulysse Ateba ^{[1
,2
,3
,4
]}

Issifou, Saadou ^{[1
,2
,3
]}

Yazdanbakhsh, Maria ^{[4
]}

Kremsner, Peter G. ^{[1
,2
,3
]}

机构：

[1] Univ Tubingen, Inst Trop Med, D-72074 Tubingen, Germany

[2] Albert Schweitzer Hosp, Lambarene, Gabon

[3] Ctr Rech Med Lambarene CERMEL, Lambarene, Gabon

[4] Leiden Univ, Med Ctr, Dept Parasitol, Leiden, Netherlands

[5] Statens Serum Inst, Dept Clin Biochem & Immunol, DK-2300 Copenhagen, Denmark

[6] Univ Copenhagen, Ctr Med Parasitol, Dept Int Hlth Immunol & Microbiol, Copenhagen, Denmark

来源：

VACCINE | 2012年 / 30卷 / 52期

关键词：

Vaccine; Trichuris trichiura; Antibody; Helminth; Malaria; HUMORAL RESPONSES; TETANUS VACCINATION; GABONESE CHILDREN; CVD; 103-HGR; INDIVIDUALS; IMPAIRMENT; INFECTION; HELMINTHS; SAFETY;

D O I：

10.1016/j.vaccine.2012.10.026

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: Helminth infections are highly prevalent in the tropics and may have an effect on immune responses to vaccines due to their immunomodulatory effect. The prevalence of helminth infections in young children, the target group for malaria and most other vaccines, is high. Therefore we assessed the influence of helminth infection on vaccine-induced immune responses in a phase I clinical trial of the malaria vaccine candidate GMZ2. Methods: Twenty Gabonese preschool-age children were vaccinated with GMZ2, a blood stage malaria vaccine candidate. Humoral immune response against the vaccine antigens and parasitological status were assessed. Vaccine-specific antibody concentrations and memory B-cell numbers were compared in worm infected and non-infected participants. Results: Antibody response to GMZ2 was 3.4-fold (95% confidence interval: 1.6, 7.4) higher in Trichuris trichiura negative subjects compared to positive participants, whereas immunoglobulin subclass distribution was similar. Memory B-cell response was moderately increased in T. trichiura negative individuals, although the difference was not significant. Conclusions: Future malaria vaccine development programs need to account for worm-mediated hyporesponsiveness of immune reactions. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：7621 / 7624

页数：4

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