A Brainstem Locomotor Circuit Drives the Activity of Speed Cells in the Medial Entorhinal Cortex

被引：38

作者：

Carvalho, Miguel M. ^{[1
,2
]}

Tanke, Nouk ^{[1
,2
,4
]}

Kropff, Emilio ^{[3
]}

Witter, Menno P. ^{[1
,2
]}

Moser, May-Britt ^{[1
,2
]}

Moser, Edvard, I ^{[1
,2
]}

机构：

[1] Norwegian Univ Sci & Technol, Kavli Inst Syst Neurosci, Olav Kyrres Gate 9, N-7491 Trondheim, Norway

[2] Norwegian Univ Sci & Technol, Ctr Neural Computat, Olav Kyrres Gate 9, N-7491 Trondheim, Norway

[3] IIBBA CONICET, Leloir Inst, Av Patricias Argentinas 435,C1405BWE, Buenos Aires, DF, Argentina

[4] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Heyendaalseweg 135, NL-6525 AJ Nijmegen, Netherlands

来源：

CELL REPORTS | 2020年 / 32卷 / 10期

基金：

欧洲研究理事会;

关键词：

SEPTUM-DIAGONAL BAND; PATH-INTEGRATION; HEAD DIRECTION; GRID CELLS; SPATIAL REPRESENTATION; THETA OSCILLATIONS; NEURAL BASIS; SELF-MOTION; RAT-BRAIN; PROJECTIONS;

D O I：

10.1016/j.celrep.2020.108123

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Locomotion activates an array of sensory inputs that may help build the self-position map of the medial entorhinal cortex (MEC). In this map, speed-coding neurons are thought to dynamically update representations of the animal's position. A possible origin for the entorhinal speed signal is the mesencephalic locomotor region (MLR), which is critically involved in the activation of locomotor programs. Here, we describe, in rats, a circuit connecting the pedunculopontine tegmental nucleus (PPN) of the MLR to the MEC via the horizontal limb of the diagonal band of Broca (HDB). At each level of this pathway, locomotion speed is linearly encoded in neuronal firing rates. Optogenetic activation of PPN cells drives locomotion and modulates activity of speed-modulated neurons in HDB and MEC. Our results provide evidence for a pathway by which brainstem speed signals can reach cortical structures implicated in navigation and higher-order dynamic representations of space.

引用

页数：22

共 88 条

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