Severe lactic acidosis induced by nucleoside analogues in an HIV-infected man

被引：24

作者：

Roy, PM ^{[1
]}

Gouello, JP ^{[1
]}

Pennison-Besnier, I ^{[1
]}

Chennebault, JM ^{[1
]}

机构：

[1] Univ Hosp, Dept Emergency Med, Angers, France

来源：

ANNALS OF EMERGENCY MEDICINE | 1999年 / 34卷 / 02期

关键词：

D O I：

10.1016/S0196-0644(99)70244-1

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Nucleoside analogues can induce myopathy or hepatitis by means of mitochondrial dysfunction. We report the case of a 31-year-old man infected with HIV who had a severe lactic acidosis without muscle or liver symptoms. He improved after hemodialysis and withdrawal of antiviral drugs. Muscle and liver evaluation allowed us to ascribe lactic acidosis to a mitochondriopathy induced by zidovudine and didanosine.

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页码：282 / 284

页数：3

相关论文

共 12 条

[1] FULMINANT-HEPATITIS WITH SEVERE LACTATE ACIDOSIS IN HIV-INFECTED PATIENTS ON DIDANOSINE THERAPY [J].

BISSUEL, F ;

BRUNEEL, F ;

HABERSETZER, F ;

CHASSARD, D ;

COTTE, L ;

CHEVALLIER, M ;

BERNUAU, J ;

LUCET, JC ;

TREPO, C .

JOURNAL OF INTERNAL MEDICINE, 1994, 235 (04) :367-371

[2] DETERMINATION OF THE BLOOD LACTATE-PYRUVATE RATIO AS A NONINVASIVE TEST FOR THE DIAGNOSIS OF ZIDOVUDINE MYOPATHY [J].

CHARIOT, P ;

MONNET, I ;

MOUCHET, M ;

ROHR, M ;

LEFAUCHEUR, JP ;

DUBREUILLEMAIRE, ML ;

CHOUSTERMAN, M ;

GHERARDI, R .

ARTHRITIS AND RHEUMATISM, 1994, 37 (04) :583-586

[3]

CHEN CH, 1991, MOL PHARMACOL, V39, P625

[4] HEPATOMEGALY WITH SEVERE STEATOSIS IN HIV-SEROPOSITIVE PATIENTS [J].

FREIMAN, JP ;

HELFERT, KE ;

HAMRELL, MR ;

STEIN, DS .

AIDS, 1993, 7 (03) :379-385

[5]

GOPINATH R, 1992, J AM SOC NEPHROL, V3, P1212

[6] HIGH-OUTPUT HEART-FAILURE IN MITOCHONDRIAL MYOPATHY - A FULMINANT FORM WITH SEVERE LACTIC-ACIDOSIS AND RHABDOMYOLYSIS [J].

HIROSE, Y ;

MIIDA, T ;

YOSHIDA, K ;

KIMURA, H ;

ODA, H ;

TOEDA, T ;

HIGUMA, N .

INTERNAL MEDICINE, 1993, 32 (10) :798-801

[7] Mitochondrial injury - Lessons from the fialuridine trial [J].

Honkoop, P ;

Scholte, HR ;

deMan, RA ;

Schalm, SW .

DRUG SAFETY, 1997, 17 (01) :1-7

[8]

Meurin P, 1996, PRESSE MED, V25, P1115

[9] ZIDOVUDINE MYOPATHY - A DISTINCTIVE DISORDER ASSOCIATED WITH MITOCHONDRIAL DYSFUNCTION [J].

MHIRI, C ;

BAUDRIMONT, M ;

BONNE, G ;

GENY, C ;

DEGOUL, F ;

MARSAC, C ;

ROULLET, E ;

GHERARDI, R .

ANNALS OF NEUROLOGY, 1991, 29 (06) :606-614

[10] LACTIC-ACIDOSIS IN CRITICAL ILLNESS [J].

MIZOCK, BA ;

FALK, JL .

CRITICAL CARE MEDICINE, 1992, 20 (01) :80-93