Immunopathological Analysis of Erdheim-Chester Disease with Massive Ascites

被引：5

作者：

Ota, Muneo ^{[1
]}

Sakamoto, Mayuko ^{[1
]}

Sato, Kojiro ^{[1
]}

Yoshida, Yoshihiro ^{[1
]}

Asanuma, Yu Funakubo ^{[1
]}

Akiyama, Yuji ^{[1
]}

Yamakawa, Mitsunori ^{[2
]}

Mimura, Toshihide ^{[1
]}

机构：

[1] Saitama Med Univ, Fac Med, Dept Rheumatol & Appl Immunol, Saitama, Japan

[2] Yamagata Univ, Fac Med, Dept Pathol Diagnost, Yamagata 990, Japan

来源：

INTERNAL MEDICINE | 2012年 / 51卷 / 19期

关键词：

Erdheim-Chester disease; histiocytosis; flow cytometry; interferon; INTERFERON-ALPHA; INVOLVEMENT;

D O I：

10.2169/internalmedicine.51.8233

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We treated a 77-year-old woman with pleural and pericardial effusion and ascites. Initially, collagen vascular disease was suspected due to the presence of anti-centromere antibodies and suspected complication of pulmonary arterial hypertension. However, soft-tissue abnormalities surrounding the bilateral kidneys detected on computed tomography (CT) and symmetrical lesions of the long bones detected on bone scintigraphy made us consider a diagnosis of Erdheim-Chester disease (ECD), which is a rare form of histiocytosis. We immunochemically analyzed the cells derived from the ascites in detail and confirmed the diagnosis. Immunocytochemical analyses may therefore help to achieve a better understanding of the pathogenesis of this rare disease.

引用

页码：2825 / 2830

页数：6

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