Non-steroidal anti-inflammatory drugs for cancer prevention: promise, perils and pharmacogenetics

被引：469

作者：

Ulrich, CM ^{[1
]}

Bigler, J ^{[1
]}

Potter, JD ^{[1
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA

来源：

NATURE REVIEWS CANCER | 2006年 / 6卷 / 02期

关键词：

D O I：

10.1038/nrc1801

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aspirin and other non-steroidal anti-inflammatory drugs ( NSAIDs) show indisputable promise as chemopreventive agents. Possible targets include cancers of the colon, stomach, breast and lung. However, recent studies raise concern about potential cardiovascular toxicity associated with the use of NSAIDs that specifically target the enzyme cyclooxygenase 2. These findings, and others that show that inherited genetic characteristics might determine preventive success, argue for new strategies that are tailored to individual medical history and genetic make-up.

引用

收藏

页码：130 / 140

页数：11

相关论文

共 50 条

[11] NON-STEROIDAL ANTI-INFLAMMATORY DRUGS [J].

不详 .

CANADIAN MEDICAL ASSOCIATION JOURNAL, 1966, 94 (07) :358-+

[12] NON-STEROIDAL ANTI-INFLAMMATORY DRUGS [J].

JACOBELLI, S .

REVISTA MEDICA DE CHILE, 1978, 106 (11) :923-931

[13] NON-STEROIDAL ANTI-INFLAMMATORY DRUGS [J].

MAYLIN, GA .

PROCEEDINGS OF THE ANNUAL CONVENTION OF THE AMERICAN ASSOCIATION OF EQUINE PRACTITIONERS, 1977, 23 (DEC) :401-406

[14] Non-steroidal anti-inflammatory drugs and brain cancer [J].

Daugherty, Sarah E. ;

Moore, Steve ;

Pfeiffer, Ruth ;

Park, Yikyung ;

Rajaraman, Preetha .

CANCER RESEARCH, 2011, 71

[15] Colorectal cancer and non-steroidal anti-inflammatory drugs [J].

Ota, S ;

Bamba, H ;

Kato, A .

ACTA PHARMACOLOGICA SINICA, 2000, 21 (05) :391-395

[16] Non-steroidal anti-inflammatory drugs and chemoprevention of cancer [J].

Vainio, H ;

Morgan, G .

ANNALES CHIRURGIAE ET GYNAECOLOGIAE, 2000, 89 (03) :173-176

[17] Non-steroidal anti-inflammatory drugs in cancer treatment [J].

Michon, P ;

Dumas, P .

POINT VETERINAIRE, 2004, 35 (250) :30-+

[18] Epidemiology of non-steroidal anti-inflammatory drugs and cancer [J].

Baron, JA .

COX-2: A NEW TARGET FOR CANCER PREVENTION AND TREATMENT, 2003, 37 :1-24

[19] Non-steroidal anti-inflammatory drugs in cancer treatment [J].

Cuendet, M ;

Pezzuto, JM .

EXPERT OPINION ON THERAPEUTIC PATENTS, 2002, 12 (06) :827-835

[20] NON-STEROIDAL ANTI-INFLAMMATORY DRUGS [J].

OBRIEN, WM .

PHARMACOLOGY, 1982, 25 :1-8

← 1 2 3 4 5 →