An efficient synthesis of dopamine transporter tracer [18F]FECNT

被引：7

作者：

Murali, D. ^{[1
]}

Barnhart, T. E. ^{[1
]}

Vandehey, N. T. ^{[1
,2
]}

Christian, B. T. ^{[1
,2
]}

Nickles, R. J. ^{[1
]}

Converse, A. K. ^{[2
]}

Larson, J. A. ^{[3
]}

Holden, J. E. ^{[1
]}

Schneider, M. L. ^{[3
]}

DeJesus, O. T. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Med Phys, Madison, WI 53705 USA

[2] Univ Wisconsin, Waisman Ctr, Madison, WI 53705 USA

[3] Univ Wisconsin, Dept Kinesiol, Madison, WI 53705 USA

来源：

APPLIED RADIATION AND ISOTOPES | 2013年 / 72卷

关键词：

F-18]FECNT; PET tracer; DAT ligands; Dopamine transporter; Positron emission tomography; PET; F-18-FECNT; REVERSAL; COCAINE; LIGAND; F-18;

D O I：

10.1016/j.apradiso.2012.10.010

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A simple synthesis of the dopamine transporter ligand [F-18]FECNT with high radiochemical yield and short synthesis time, suitable for routine production is reported. Reaction of 2 beta-carbomethoxy-3 beta-(4-chlorophenyl)nortropane with [F-18]2-fluoroethyl triflate ([F-18]FEtOTf) at room temperature for 4 min provided [F-18]FECNT in 84% decay corrected radiochemical yield. Since [F-18]FEtOTf was prepared from [F-18]2-fluoroethyl bromide that was isolated from its starting material, formation of unwanted side products and the amount of expensive precursor used could be greatly reduced. The overall radiochemical ;yields of [F-18]FECNT were 40% (n=29) and the total synthesis time was ca. 100 min. The average specific activity of [F-18]FECNT was 377.4 GBq/mu mol (10.2 Ci/mu mol). (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：128 / 132

页数：5

共 18 条

[1]

[Anonymous], INT J RAD APPL INS A

[2] Neurobiology - Dopamine's reversal of fortune [J].