Magnetic targeting core/shell Fe3O4/Au nanoparticles for magnetic resonance/photoacoustic dual-modal imaging

被引：34

作者：

Kang, Ning ^{[1
]}

Xu, Dan ^{[1
]}

Han, Yu ^{[1
]}

Lv, Xiaolin ^{[1
]}

Chen, Zhiwei ^{[2
]}

Zhou, Tiantian ^{[2
]}

Ren, Lei ^{[1
,3
]}

Zhou, Xi ^{[1
,3
]}

机构：

[1] Xiamen Univ, Coll Mat, Dept Biomat, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R China

[2] Xiamen Univ, Dept Elect Sci, Fujian Prov Key Lab Plasma & Magnet Resonance Res, Xiamen 361005, Peoples R China

[3] Fujian Collaborat Innovat Ctr Exploitat & Utiliza, Xiamen 361005, Peoples R China

来源：

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2019年 / 98卷

基金：

美国国家科学基金会;

关键词：

Fe3O4/Au nanoparticles; Dual-modal imaging; MR imaging; PA imaging; Magnetic targeting; MULTIMODALITY; DESIGN; MRI;

D O I：

10.1016/j.msec.2019.01.013

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

This study reports magnetic targeting guided magnetic (MR)/photoacoustic (PA) dual-modal imaging by core/shell Fe3O4/Au nanoparticles. In this work, MR imaging provides time-dependent tumor location, and PA imaging reveals high resolution vasculatures inside the tumor. It is noted that the synthesized Fe3O4/Au nanoparticles exhibited higher r(2) value up to 329 mM(-1) s(-1) than previously reported T-2 contrast agents. Furthermore, the Fe3O4/Au NPs are applied as a promising candidate for in vivo MR/PA imaging of tumors by intravenously injection into LNCaP tumor-beared mice. The MR/PA imaging results show a significantly enhanced MR/PA images in the tumor site. The prepared core/shell Fe3O4/Au nanoparticles will be widely applicable in multi-modal imaging.

引用

收藏

页码：545 / 549

页数：5

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