Apolipoprotein B/apolipoprotein A1 ratio is a good predictive marker of metabolic syndrome and pre-metabolic syndrome in Chinese adolescent women with polycystic ovary syndrome

被引:36
作者
Yin, Qianqian [1 ]
Chen, Xiaoli [1 ]
Li, Lin [1 ]
Zhou, Ran [1 ]
Huang, Jia [1 ]
Yang, Dongzi [1 ]
机构
[1] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Obstet & Gynecol, Guangzhou 510120, Guangdong, Peoples R China
基金
中国国家自然科学基金;
关键词
adolescent; ApoB; ApoA1; ratio; metabolic syndrome; polycystic ovary syndrome; pre-metabolic syndrome; CARDIOVASCULAR RISK; INSULIN-RESISTANCE; APOB/APOA-1; RATIO; CHILDREN; PREVALENCE; LIPOPROTEINS; CRITERIA;
D O I
10.1111/j.1447-0756.2012.01907.x
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Aim: The apolipoprotein B/apolipoprotein A1 (ApoB/ApoA1) ratio is well known to be related to metabolic syndrome (MS) and its components in adults of different races. There is low prevalence of MS but high occurrence of various metabolic disorders in Chinese adolescent women with polycystic ovary syndrome (PCOS). We sought to assess if the ApoB/ApoA1 ratio can be used as a predictive marker of MS and pre-MS in Chinese adolescent women with PCOS. Material and Methods: This cross-sectional study included 160 Chinese adolescent women. Based on International Diabetes Federation criteria for MS, patients who had no less than two components of MS but did not meet the criteria for the diagnosis of MS were considered as having pre-MS. Results: The ApoB/ApoA1 ratio was higher in obese subjects with high free androgen index (FAI). The ApoB/ApoA1 ratio increased significantly as the number of MS components increased and provided 87.5% of sensitivity and 78.9% of specificity with a threshold value of 0.63 for MS, 86.2% of sensitivity and 79.4% of specificity with a threshold value of 0.58 for pre-MS in Chinese adolescent women with PCOS. Conclusion: The ApoB/ApoA1 ratio was a good predictive marker of MS and pre-MS in Chinese adolescent women with PCOS. FAI could be involved in obesity-related metabolic abnormalities.
引用
收藏
页码:203 / 209
页数:7
相关论文
共 27 条
[1]   The rationale for using apoA-I as a clinical marker of cardiovascular risk [J].
Barter, PJ ;
Rye, KA .
JOURNAL OF INTERNAL MEDICINE, 2006, 259 (05) :447-454
[2]   Cardiovascular risk in women with polycystic ovarian syndrome (PCOS) [J].
Bickerton, AST ;
Clark, N ;
Meeking, D ;
Shaw, KM ;
Crook, M ;
Lumb, P ;
Turner, C ;
Cummings, MH .
JOURNAL OF CLINICAL PATHOLOGY, 2005, 58 (02) :151-154
[3]   Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome [J].
Chang, J ;
Azziz, R ;
Legro, R ;
Dewailly, D ;
Franks, S ;
Tarlatzis, BC ;
Fauser, B ;
Balen, A ;
Bouchard, P ;
Dahlgren, E ;
Devoto, L ;
Diamanti, E ;
Dunaif, A ;
Filicori, M ;
Homburg, R ;
Ibanez, L ;
Laven, J ;
Magoffin, D ;
Nestler, J ;
Norman, RJ ;
Pasquali, R ;
Pugeat, M ;
Strauss, J ;
Tan, S ;
Taylor, A ;
Wild, R ;
Wild, S ;
Ehrmann, D ;
Lobo, R .
FERTILITY AND STERILITY, 2004, 81 (01) :19-25
[4]   Prevalence of polycystic ovary syndrome in unselected women from southern China [J].
Chen, Xiaoli ;
Yang, Dongzi ;
Mo, Yaqin ;
Li, Lin ;
Chen, Yaxiao ;
Huang, Yuhong .
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2008, 139 (01) :59-64
[5]   Adolescent girls with polycystic ovary syndrome have an increased risk of the metabolic syndrome associated with increasing androgen levels independent of obesity and insulin resistance [J].
Coviello, AD ;
Legro, RS ;
Dunaif, A .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (02) :492-497
[6]  
Daniilidis A, 2009, HIPPOKRATIA, V13, P90
[7]   Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome [J].
Ehrmann, DA ;
Liljenquist, DR ;
Kasza, K ;
Azziz, R ;
Legro, RS ;
Ghazzi, MN .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (01) :48-53
[8]   Utility of ApoB/ApoA1 Ratio for the Prediction of Cardiovascular Risk in Children with Metabolic Syndrome [J].
Erdeve, Senay Savas ;
Simsek, Enver ;
Dallar, Yildiz ;
Biyikli, Zeynep .
INDIAN JOURNAL OF PEDIATRICS, 2010, 77 (11) :1261-1265
[9]   Effect of flutamide and metformin administered alone or in combination in dieting obese women with polycystic ovary syndrome [J].
Gambineri, A ;
Pelusi, C ;
Genghini, S ;
Morselli-Labate, AM ;
Cacciari, M ;
Pagotto, U ;
Pasquali, R .
CLINICAL ENDOCRINOLOGY, 2004, 60 (02) :241-249
[10]   Low-density lipoprotein and oxidised low-density lipoprotein: Their role in the development of atherosclerosis [J].
Hamilton, CA .
PHARMACOLOGY & THERAPEUTICS, 1997, 74 (01) :55-72